Synthesis of indoles from aroyloxycarbamates with alkynes: Via decarboxylation/cyclization

Nuannuan Ma, Peihe Li, Zheng Wang, Qipu Dai*, Changwen Hu

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

7 引用 (Scopus)

摘要

An efficient Pd-catalyzed decarboxylation/cyclization of aroyloxycarbamates to realize substituted indoles has been disclosed. Terminal alkynes as the coupling partners lead to site specific 2-substituted indoles through two pathways, while internal alkynes with aroyloxycarbamates can be transformed to 2,3-disubstituted indoles directly. This protocol is further demonstrated by the efficient synthesis of indoles as well as the success of employing inexpensive aryl acids as starting materials to construct C-N bonds by releasing CO2.

源语言英语
页(从-至)2421-2426
页数6
期刊Organic and Biomolecular Chemistry
16
14
DOI
出版状态已出版 - 2018

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