摘要
An efficient Pd-catalyzed decarboxylation/cyclization of aroyloxycarbamates to realize substituted indoles has been disclosed. Terminal alkynes as the coupling partners lead to site specific 2-substituted indoles through two pathways, while internal alkynes with aroyloxycarbamates can be transformed to 2,3-disubstituted indoles directly. This protocol is further demonstrated by the efficient synthesis of indoles as well as the success of employing inexpensive aryl acids as starting materials to construct C-N bonds by releasing CO2.
源语言 | 英语 |
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页(从-至) | 2421-2426 |
页数 | 6 |
期刊 | Organic and Biomolecular Chemistry |
卷 | 16 |
期 | 14 |
DOI | |
出版状态 | 已出版 - 2018 |