Synthesis and in vitro cytotoxicity of a novel conjugate of polyamide and phospholipid

Yi Liu; Yu Lin Deng; Rong Zheng; Pei Long Zhang; Hui Zhai; Ke Zhong Liu; Chang Jin Zhu

Synthesis and in vitro cytotoxicity of a novel conjugate of polyamide and phospholipid

Yi Liu^*, Yu Lin Deng, Rong Zheng, Pei Long Zhang, Hui Zhai, Ke Zhong Liu, Chang Jin Zhu

^*此作品的通讯作者

医学技术学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

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摘要

In order to increase the cell penetration and decrease the cytotoxicity of the synthetic molecule, we designed and synthesized a DNA-binding ligand, which was a conjugate of polyamide and phospholipid. We examined the differences in the effect on cytotoxicity between the conjugate and the native polyamide. As expected that the in vitro cytotoxicity of the conjugate was obviously lower than that of the native polyamide either in HeLa cells or SH-SY5Y neuroblastoma cells.

源语言	英语
页（从-至）	599-602
页数	4
期刊	Chinese Chemical Letters
卷	17
期	5
出版状态	已出版 - 5月 2006

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title = "Synthesis and in vitro cytotoxicity of a novel conjugate of polyamide and phospholipid",

abstract = "In order to increase the cell penetration and decrease the cytotoxicity of the synthetic molecule, we designed and synthesized a DNA-binding ligand, which was a conjugate of polyamide and phospholipid. We examined the differences in the effect on cytotoxicity between the conjugate and the native polyamide. As expected that the in vitro cytotoxicity of the conjugate was obviously lower than that of the native polyamide either in HeLa cells or SH-SY5Y neuroblastoma cells.",

keywords = "Cytotoxicity, Phospholipid conjugate, Polyamide",

author = "Yi Liu and Deng, {Yu Lin} and Rong Zheng and Zhang, {Pei Long} and Hui Zhai and Liu, {Ke Zhong} and Zhu, {Chang Jin}",

year = "2006",

month = may,

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pages = "599--602",

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T1 - Synthesis and in vitro cytotoxicity of a novel conjugate of polyamide and phospholipid

AU - Liu, Yi

AU - Deng, Yu Lin

AU - Zheng, Rong

AU - Zhang, Pei Long

AU - Zhai, Hui

AU - Liu, Ke Zhong

AU - Zhu, Chang Jin

PY - 2006/5

Y1 - 2006/5

N2 - In order to increase the cell penetration and decrease the cytotoxicity of the synthetic molecule, we designed and synthesized a DNA-binding ligand, which was a conjugate of polyamide and phospholipid. We examined the differences in the effect on cytotoxicity between the conjugate and the native polyamide. As expected that the in vitro cytotoxicity of the conjugate was obviously lower than that of the native polyamide either in HeLa cells or SH-SY5Y neuroblastoma cells.

AB - In order to increase the cell penetration and decrease the cytotoxicity of the synthetic molecule, we designed and synthesized a DNA-binding ligand, which was a conjugate of polyamide and phospholipid. We examined the differences in the effect on cytotoxicity between the conjugate and the native polyamide. As expected that the in vitro cytotoxicity of the conjugate was obviously lower than that of the native polyamide either in HeLa cells or SH-SY5Y neuroblastoma cells.

KW - Cytotoxicity

KW - Phospholipid conjugate

KW - Polyamide

UR - http://www.scopus.com/inward/record.url?scp=33745836747&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33745836747

SN - 1001-8417

VL - 17

SP - 599

EP - 602

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 5

ER -

Synthesis and in vitro cytotoxicity of a novel conjugate of polyamide and phospholipid

摘要

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