Study on synthesis, crystal structure and anticancer activity of complex cis-[Pd(bipy-ethyl)Cl₂]

The complex cis-[Pd(bipy-ethyl)Cl₂] (bipy-ethyl=2,2′- bipyridine-3-ethyl formate)was synthesized under hydrothermal conditions. X-ray crystal structure analysis was carried out to determine the crystal structure of the title complex. The crystal of the title complex belongs to orthorhombic system with space group Pbca. The Pd²⁺ ions was coordinated by two nitrogen atoms of bipy-ethyl and two terminal chlorine ions, rendering a quadrangle geometry. There are abundant C-H ··· CI interaction, C-H ··· O interaction and Pd-Aromatic interaction between adjacent complexes. The inhibitory activity of complex with cancer cell of Hela, Hep-G2 and KB were mensurated by vitro activity methods. The result shows that although inhibitory activity of complex is not as good as cis-DDP, the complex still has strong ability to kill cancer cell.