Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy

Yanyan Cui; Jian Yang; Qunfang Zhou; Ping Liang; Yaling Wang; Xueyun Gao; Yongtian Wang

doi:10.1021/acsami.6b16133

Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy

Yanyan Cui^*, Jian Yang, Qunfang Zhou, Ping Liang, Yaling Wang, Xueyun Gao, Yongtian Wang

^*此作品的通讯作者

光电学院

科研成果: 期刊稿件 › 文章 › 同行评审

70 引用（Scopus）

摘要

Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.

源语言	英语
页（从-至）	5900-5906
页数	7
期刊	ACS applied materials & interfaces
卷	9
期	7
DOI	https://doi.org/10.1021/acsami.6b16133
出版状态	已出版 - 22 2月 2017

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abstract = "Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.",

keywords = "X-ray CT imaging, photothermal therapy, protein, renal clearable, silver nanodots",

author = "Yanyan Cui and Jian Yang and Qunfang Zhou and Ping Liang and Yaling Wang and Xueyun Gao and Yongtian Wang",

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AU - Cui, Yanyan

AU - Yang, Jian

AU - Zhou, Qunfang

AU - Liang, Ping

AU - Wang, Yaling

AU - Gao, Xueyun

AU - Wang, Yongtian

PY - 2017/2/22

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N2 - Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.

AB - Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.

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Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy

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