Rational design of pyrrole derivatives with aggregation-induced phosphorescence characteristics for time-resolved and two-photon luminescence imaging

Jianhui Yang, Yahui Zhang, Xinghui Wu, Wenbo Dai, Dan Chen, Jianbing Shi, Bin Tong, Qian Peng, Haiyan Xie, Zhengxu Cai*, Yuping Dong, Xin Zhang*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

108 引用 (Scopus)

摘要

Pure organic room-temperature phosphorescent (RTP) materials have been suggested to be promising bioimaging materials due to their good biocompatibility and long emission lifetime. Herein, we report a class of RTP materials. These materials are developed through the simple introduction of an aromatic carbonyl to a tetraphenylpyrrole molecule and also exhibit aggregation-induced emission (AIE) properties. These molecules show non-emission in solution and purely phosphorescent emission in the aggregated state, which are desirable properties for biological imaging. Highly crystalline nanoparticles can be easily fabricated with a long emission lifetime (20 μs), which eliminate background fluorescence interference from cells and tissues. The prepared nanoparticles demonstrate two-photon absorption characteristics and can be excited by near infrared (NIR) light, making them promising materials for deep-tissue optical imaging. This integrated aggregation-induced phosphorescence (AIP) strategy diversifies the existing pool of bioimaging agents to inspire the development of bioprobes in the future.

源语言英语
文章编号4883
期刊Nature Communications
12
1
DOI
出版状态已出版 - 1 12月 2021

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