Protein remote homology detection using order profiles

Bin Liu*, Lei Lin, Xiaolong Wang, Xuan Wang

*此作品的通讯作者

科研成果: 书/报告/会议事项章节会议稿件同行评审

2 引用 (Scopus)

摘要

Protein remote homology detection is a central problem in bioinformatics. In this study, we present a novel building block of proteins called order profiles (OP) to use the evolutionary information of the protein sequence frequency profiles and apply this novel building block to remote homology detection. Order profiles contain the evolutionary information extracted from the protein sequence frequency profiles outputted by PSI-BLAST. The performance of our method is further improved by applying an efficient feature extraction algorithm from natural language processing, namely, latent semantic analysis (LSA). When tested on SCOP 1.53 benchmark, our method outperforms the other building-block-based methods and related methods.

源语言英语
主期刊名Proceedings - 2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009
255-260
页数6
DOI
出版状态已出版 - 2009
已对外发布
活动2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009 - Shanghai, 中国
期限: 3 8月 20095 8月 2009

出版系列

姓名Proceedings - 2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009

会议

会议2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009
国家/地区中国
Shanghai
时期3/08/095/08/09

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引用此

Liu, B., Lin, L., Wang, X., & Wang, X. (2009). Protein remote homology detection using order profiles. 在 Proceedings - 2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009 (页码 255-260). 文章 5260671 (Proceedings - 2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009). https://doi.org/10.1109/IJCBS.2009.53