TY - GEN
T1 - Protein fold recognition and remote homology detection based on profile-level building blocks
AU - Lin, Lei
AU - Shen, Yi
AU - Liu, Bin
AU - Wang, Xiaolong
PY - 2010
Y1 - 2010
N2 - Protein remote homology detection and fold recognition are central problems in bioinformatics. In this paper, two kinds of profile-level building blocks of protein sequences, binary profiles and N-nary profiles, are presented, which contain the evolutionary information of the protein sequence frequency profile. The two building blocks are applied for protein remote homology and fold detection tasks. The latent semantic analysis (LSA) model is adopted to further improve the performance of our methods. Experiment results show that the methods based on profile-level building blocks give better results compared to related methods.
AB - Protein remote homology detection and fold recognition are central problems in bioinformatics. In this paper, two kinds of profile-level building blocks of protein sequences, binary profiles and N-nary profiles, are presented, which contain the evolutionary information of the protein sequence frequency profile. The two building blocks are applied for protein remote homology and fold detection tasks. The latent semantic analysis (LSA) model is adopted to further improve the performance of our methods. Experiment results show that the methods based on profile-level building blocks give better results compared to related methods.
KW - Fold recognition
KW - Latent semantic analysis
KW - Remote homology detection
KW - Support vector machine
UR - http://www.scopus.com/inward/record.url?scp=77953320348&partnerID=8YFLogxK
U2 - 10.1109/ICBECS.2010.5462512
DO - 10.1109/ICBECS.2010.5462512
M3 - Conference contribution
AN - SCOPUS:77953320348
SN - 9781424453153
T3 - 2010 International Conference on Biomedical Engineering and Computer Science, ICBECS 2010
BT - 2010 International Conference on Biomedical Engineering and Computer Science, ICBECS 2010
T2 - 2010 International Conference on Biomedical Engineering and Computer Science, ICBECS 2010
Y2 - 23 April 2010 through 25 April 2010
ER -