Properties study on hydroxypropyl methylcellulose trimellitate

Wen Jun Wang; Zi Qiang Shao; Ya Qing Xu; Yong Hong Li; Li Zhang; Bing Liao

Properties study on hydroxypropyl methylcellulose trimellitate

Wen Jun Wang^*, Zi Qiang Shao, Ya Qing Xu, Yong Hong Li, Li Zhang, Bing Liao

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材料学院

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摘要

Synthesized a novel kind of enteric-coating material-HPMCT. Its structure and application properties such as dissolving ability in different organic solvent, pH sensibility, coating technical properties and dissolution rate in buffer solution (pH = 6.86) were analyzed by IR and UV. The results indicated that ethanol/methylene chloride, acetone/ethanol/water, acetone/ethanol and ethanol/water were all good solvent systems for the HPMCT; the pH sensibility value range of the HPMCT is 3.8-4.0, the HPMCT can dissolve rapidly in buffer solution (pH = 6.86), achieving tight, smooth and having metallic brightness coating without plasticizer. Dissolution rate of the coated tablet in buffer solution (pH = 6.86) in 20 minutes were 92.60%, which meet the necessity of enteric coating material.

源语言	英语
页（从-至）	270-273
页数	4
期刊	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
卷	29
期	3
出版状态	已出版 - 3月 2009

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Wang, W. J., Shao, Z. Q., Xu, Y. Q., Li, Y. H., Zhang, L., & Liao, B. (2009). Properties study on hydroxypropyl methylcellulose trimellitate. Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology, 29(3), 270-273.

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title = "Properties study on hydroxypropyl methylcellulose trimellitate",

abstract = "Synthesized a novel kind of enteric-coating material-HPMCT. Its structure and application properties such as dissolving ability in different organic solvent, pH sensibility, coating technical properties and dissolution rate in buffer solution (pH = 6.86) were analyzed by IR and UV. The results indicated that ethanol/methylene chloride, acetone/ethanol/water, acetone/ethanol and ethanol/water were all good solvent systems for the HPMCT; the pH sensibility value range of the HPMCT is 3.8-4.0, the HPMCT can dissolve rapidly in buffer solution (pH = 6.86), achieving tight, smooth and having metallic brightness coating without plasticizer. Dissolution rate of the coated tablet in buffer solution (pH = 6.86) in 20 minutes were 92.60%, which meet the necessity of enteric coating material.",

keywords = "Enteric-coating, Hydroxypropyl methylcellulose trimellitate, PH sensibility",

author = "Wang, {Wen Jun} and Shao, {Zi Qiang} and Xu, {Ya Qing} and Li, {Yong Hong} and Li Zhang and Bing Liao",

year = "2009",

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TY - JOUR

T1 - Properties study on hydroxypropyl methylcellulose trimellitate

AU - Wang, Wen Jun

AU - Shao, Zi Qiang

AU - Xu, Ya Qing

AU - Li, Yong Hong

AU - Zhang, Li

AU - Liao, Bing

PY - 2009/3

Y1 - 2009/3

N2 - Synthesized a novel kind of enteric-coating material-HPMCT. Its structure and application properties such as dissolving ability in different organic solvent, pH sensibility, coating technical properties and dissolution rate in buffer solution (pH = 6.86) were analyzed by IR and UV. The results indicated that ethanol/methylene chloride, acetone/ethanol/water, acetone/ethanol and ethanol/water were all good solvent systems for the HPMCT; the pH sensibility value range of the HPMCT is 3.8-4.0, the HPMCT can dissolve rapidly in buffer solution (pH = 6.86), achieving tight, smooth and having metallic brightness coating without plasticizer. Dissolution rate of the coated tablet in buffer solution (pH = 6.86) in 20 minutes were 92.60%, which meet the necessity of enteric coating material.

AB - Synthesized a novel kind of enteric-coating material-HPMCT. Its structure and application properties such as dissolving ability in different organic solvent, pH sensibility, coating technical properties and dissolution rate in buffer solution (pH = 6.86) were analyzed by IR and UV. The results indicated that ethanol/methylene chloride, acetone/ethanol/water, acetone/ethanol and ethanol/water were all good solvent systems for the HPMCT; the pH sensibility value range of the HPMCT is 3.8-4.0, the HPMCT can dissolve rapidly in buffer solution (pH = 6.86), achieving tight, smooth and having metallic brightness coating without plasticizer. Dissolution rate of the coated tablet in buffer solution (pH = 6.86) in 20 minutes were 92.60%, which meet the necessity of enteric coating material.

KW - Enteric-coating

KW - Hydroxypropyl methylcellulose trimellitate

KW - PH sensibility

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M3 - Article

AN - SCOPUS:64749092860

SN - 1001-0645

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JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 3

ER -

Properties study on hydroxypropyl methylcellulose trimellitate

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