Optimized fluorodendrimer-incorporated hybrid lipid-polymer nanoparticles for efficient siRNA delivery

Qingqing Xiong, Yujing Li, Kun Zhou, Ping Chen, Hua Guo, Lu Chen, Jianxun Ding, Tianqiang Song, Jinjun Shi

科研成果: 期刊稿件文章同行评审

17 引用 (Scopus)

摘要

Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.

源语言英语
页(从-至)758-762
页数5
期刊Biomaterials Science
8
3
DOI
出版状态已出版 - 20 2月 2020
已对外发布

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