One-Pot Synthesis of Customized Metal–Phenolic-Network-Coated AIE Dots for In Vivo Bioimaging

Changhuo Xu, Chen Peng*, Xueqin Yang, Ruoyao Zhang, Zheng Zhao*, Bo Yan, Jun Zhang, Junyi Gong, Xuewen He, Ryan T.K. Kwok, Jacky W.Y. Lam, Ben Zhong Tang*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

26 引用 (Scopus)

摘要

The integration of aggregation-induced emission luminogens (AIEgens) and inorganic constituents to generate multifunctional nanocomposites has attracted much attention because it couples the bright aggregate-state fluorescence of AIEgens with the diverse imaging modalities of inorganic constituents. Herein, a facile and universal strategy to prepare metal–phenolic-network (MPN)-coated AIE dots in a high encapsulation efficiency is reported. Through precise control on the nucleation of AIEgens and deposition of MPNs in tetrahydrofuran/water mixtures, termed as coacervation, core–shell MPN-coated AIE dots with bright emission are assembled in a one-pot fashion. The optical properties of MPN-coated AIE dots can be readily tuned by varying the incorporated AIEgens. Different metal ions, such as Fe3+, Ti4+, Cu2+, Ni2+, can be introduced to the nanoparticles. The MPN-coated AIE dots with a red-emissive AIEgen core are successfully used to perform magnetic resonance/fluorescence dual-modality imaging in a tumor-bearing mouse model and blood flow visualization in a zebrafish larva. It is believed that the present study provides a tailor-made nanoplatform to meet the individual needs of in vivo bioimaging.

源语言英语
文章编号2104997
期刊Advanced Science
9
11
DOI
出版状态已出版 - 14 4月 2022
已对外发布

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