Xu, K., Qin, L., Wang, X., Bai, W., Li, F., Ren, S., Gao, X., Chen, B., Tong, Y., Li, J., Li, B. Z., Yuan, Y. J., & Li, C. (2020). Multilevel Defense System (MDS) Relieves Multiple Stresses for Economically Boosting Ethanol Production of Industrial Saccharomyces cerevisiae. ACS Energy Letters, 5(2), 572-582. https://doi.org/10.1021/acsenergylett.9b02681
Xu, Ke ; Qin, Lei ; Wang, Xiaoyan 等. / Multilevel Defense System (MDS) Relieves Multiple Stresses for Economically Boosting Ethanol Production of Industrial Saccharomyces cerevisiae. 在: ACS Energy Letters. 2020 ; 卷 5, 号码 2. 页码 572-582.
@article{95f9678fdf9a4a7ab68899f80658399b,
title = "Multilevel Defense System (MDS) Relieves Multiple Stresses for Economically Boosting Ethanol Production of Industrial Saccharomyces cerevisiae",
abstract = "In the biofuel industry, improving the tolerance of Saccharomyces cerevisiae to the multiple stresses is essential to enhance the production efficiency and reduce the economic cost. We herein developed a multilevel defense system (MDS) by random assembly of tolerance genetic circuits, adaptive evolution, and multistep screening to obtain industrial yeasts with higher robustness and productivity. MDS was applied to increase the ethanol concentration by 6.9% in industrial pilotscale fermentation at high temperature, and the energy consumption for the cooling was decreased by 45.1% compared with that for the normal process. Furthermore, MDS showed a significant effect on relieving the multiple stresses by reducing intracellular reactive oxygen species (ROS) and balancing the productive transcriptional performance. This system offers a new solution for remolding industrial yeast and may accelerate further development of ethanol refinery.",
author = "Ke Xu and Lei Qin and Xiaoyan Wang and Wenxin Bai and Fan Li and Shichao Ren and Xiaopeng Gao and Bo Chen and Yi Tong and Jun Li and Li, {Bing Zhi} and Yuan, {Ying Jin} and Chun Li",
note = "Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",
year = "2020",
month = feb,
day = "14",
doi = "10.1021/acsenergylett.9b02681",
language = "English",
volume = "5",
pages = "572--582",
journal = "ACS Energy Letters",
issn = "2380-8195",
publisher = "American Chemical Society",
number = "2",
}
Xu, K, Qin, L, Wang, X, Bai, W, Li, F, Ren, S, Gao, X, Chen, B, Tong, Y, Li, J, Li, BZ, Yuan, YJ & Li, C 2020, 'Multilevel Defense System (MDS) Relieves Multiple Stresses for Economically Boosting Ethanol Production of Industrial Saccharomyces cerevisiae', ACS Energy Letters, 卷 5, 号码 2, 页码 572-582. https://doi.org/10.1021/acsenergylett.9b02681
Multilevel Defense System (MDS) Relieves Multiple Stresses for Economically Boosting Ethanol Production of Industrial Saccharomyces cerevisiae. / Xu, Ke; Qin, Lei; Wang, Xiaoyan 等.
在:
ACS Energy Letters, 卷 5, 号码 2, 14.02.2020, 页码 572-582.
科研成果: 期刊稿件 › 文章 › 同行评审
TY - JOUR
T1 - Multilevel Defense System (MDS) Relieves Multiple Stresses for Economically Boosting Ethanol Production of Industrial Saccharomyces cerevisiae
AU - Xu, Ke
AU - Qin, Lei
AU - Wang, Xiaoyan
AU - Bai, Wenxin
AU - Li, Fan
AU - Ren, Shichao
AU - Gao, Xiaopeng
AU - Chen, Bo
AU - Tong, Yi
AU - Li, Jun
AU - Li, Bing Zhi
AU - Yuan, Ying Jin
AU - Li, Chun
N1 - Publisher Copyright:
© 2020 American Chemical Society.
PY - 2020/2/14
Y1 - 2020/2/14
N2 - In the biofuel industry, improving the tolerance of Saccharomyces cerevisiae to the multiple stresses is essential to enhance the production efficiency and reduce the economic cost. We herein developed a multilevel defense system (MDS) by random assembly of tolerance genetic circuits, adaptive evolution, and multistep screening to obtain industrial yeasts with higher robustness and productivity. MDS was applied to increase the ethanol concentration by 6.9% in industrial pilotscale fermentation at high temperature, and the energy consumption for the cooling was decreased by 45.1% compared with that for the normal process. Furthermore, MDS showed a significant effect on relieving the multiple stresses by reducing intracellular reactive oxygen species (ROS) and balancing the productive transcriptional performance. This system offers a new solution for remolding industrial yeast and may accelerate further development of ethanol refinery.
AB - In the biofuel industry, improving the tolerance of Saccharomyces cerevisiae to the multiple stresses is essential to enhance the production efficiency and reduce the economic cost. We herein developed a multilevel defense system (MDS) by random assembly of tolerance genetic circuits, adaptive evolution, and multistep screening to obtain industrial yeasts with higher robustness and productivity. MDS was applied to increase the ethanol concentration by 6.9% in industrial pilotscale fermentation at high temperature, and the energy consumption for the cooling was decreased by 45.1% compared with that for the normal process. Furthermore, MDS showed a significant effect on relieving the multiple stresses by reducing intracellular reactive oxygen species (ROS) and balancing the productive transcriptional performance. This system offers a new solution for remolding industrial yeast and may accelerate further development of ethanol refinery.
UR - http://www.scopus.com/inward/record.url?scp=85086742774&partnerID=8YFLogxK
U2 - 10.1021/acsenergylett.9b02681
DO - 10.1021/acsenergylett.9b02681
M3 - Article
AN - SCOPUS:85086742774
SN - 2380-8195
VL - 5
SP - 572
EP - 582
JO - ACS Energy Letters
JF - ACS Energy Letters
IS - 2
ER -
Xu K, Qin L, Wang X, Bai W, Li F, Ren S 等. Multilevel Defense System (MDS) Relieves Multiple Stresses for Economically Boosting Ethanol Production of Industrial Saccharomyces cerevisiae. ACS Energy Letters. 2020 2月 14;5(2):572-582. doi: 10.1021/acsenergylett.9b02681