Image quality and stenosis assessment of non-contrast-enhanced 3-t magnetic resonance angiography in patients with peripheral artery disease compared with contrast-enhanced magnetic resonance angiography and digital subtraction angiography

Jiayi Liu, Nan Zhang, Zhaoyang Fan, Nan Luo, Yike Zhao, Xiaoming Bi, Jing An, Zhong Chen, Dongting Liu, Zhaoying Wen, Zhanming Fan, Debiao Li

科研成果: 期刊稿件文章同行评审

11 引用 (Scopus)

摘要

Purpose To evaluate the diagnostic performance of flow-sensitive dephasing (FSD)-prepared steady-state free precession (SSFP) magnetic resonance angiography (MRA) at 3 T for imaging infragenual arteries relative to contrast-enhanced MRA (CE-MRA) and digital subtraction angiography (DSA). Materials and Methods A series of 16 consecutive patients with peripheral arterial disease (PAD) underwent a combined peripheral MRA protocol consisting of FSD-MRA for the calves and large field-of-view CE-MRA. DSA was performed on all patients within 1 week of the MR angiographies. Image quality and degree of stenosis was assessed by two readers with rich experience. Interobserver agreement was determined using kappa statistics. Receiver operating characteristic (ROC) curve analysis determined the diagnostic value of FSD-MRA, CE-MRA, and CEMRA combined with FSD-MRA (CE+FSD MRA) in predicting vascular stenosis. Results At the calf station, no significantly difference of subjective image quality scores was found between FSD-MRA and CE-MRA. Inter-reader agreement was excellent for both FSD-MRA and CE-MRA. Both of FSD-MRA and CE-MRA carry a stenosis overestimation risk relative to DSA standard. With DSA as the reference standard, ROC curve analysis showed that the area under the curve was largest for CE+FSD MRA. The greatest sensitivity and specificity were obtained when a cut-off stenosis score of 2 was used. Conclusion In patients with severe PAD,3 T FSD-MRA provides good-quality diagnostic images without a contrast agent and is a good supplement for CE-MRA. CE+FSD MRA can improve the accuracy of vascular stenosis diagnosis.

源语言英语
文章编号e0166467
期刊PLoS ONE
11
11
DOI
出版状态已出版 - 11月 2016
已对外发布

指纹

探究 'Image quality and stenosis assessment of non-contrast-enhanced 3-t magnetic resonance angiography in patients with peripheral artery disease compared with contrast-enhanced magnetic resonance angiography and digital subtraction angiography' 的科研主题。它们共同构成独一无二的指纹。

引用此