TY - JOUR
T1 - Green Synthesis of 7,8-Difluoro-6, 11-Dihydrodibenz[B,E]Thiophene-11-One of Baloxavir Marboxil - Reducing Environmental Pollution
AU - Wang, Jiaru
AU - Ru, Mengdi
AU - Meng, Zihui
AU - Xu, Zhibing
N1 - Publisher Copyright:
© The Authors, published by EDP Sciences.
PY - 2023/7/31
Y1 - 2023/7/31
N2 - Baloxavir marboxil is a novel anti-influenza drug with a unique mechanism of action that can effectively treat both type A and type B influenza. Key intermediate compound 7,8-difluoro-6,11-dihydrodibenz[b,e]thiophene-11-one is not only an important component of the chemical structure of baloxavir marboxil but also an essential intermediate in the synthetic route of the drug. However, conventional synthesis methods for key intermediate 7,8-difluoro-6,11-dihydrodibenz[b,e]thiophene-11-one usually utilize dangerous and harmful chemicals that can cause significant environmental pollution during large-scale production. This article proposes a new synthesis route for 7,8-difluoro-6,11-dihydrodibenz[b,e]thiophene-11-one to facilitate large-scale production while integrating the principles of green chemistry. This new route feature mild reaction conditions and simpler steps that result in an overall yield increase to 64.9%. More significantly, the new synthesis route reduces the use of hazardous chemicals, thus limiting the generation of hazardous waste during industrial production. This research offers significant potential for environmental pollution control.
AB - Baloxavir marboxil is a novel anti-influenza drug with a unique mechanism of action that can effectively treat both type A and type B influenza. Key intermediate compound 7,8-difluoro-6,11-dihydrodibenz[b,e]thiophene-11-one is not only an important component of the chemical structure of baloxavir marboxil but also an essential intermediate in the synthetic route of the drug. However, conventional synthesis methods for key intermediate 7,8-difluoro-6,11-dihydrodibenz[b,e]thiophene-11-one usually utilize dangerous and harmful chemicals that can cause significant environmental pollution during large-scale production. This article proposes a new synthesis route for 7,8-difluoro-6,11-dihydrodibenz[b,e]thiophene-11-one to facilitate large-scale production while integrating the principles of green chemistry. This new route feature mild reaction conditions and simpler steps that result in an overall yield increase to 64.9%. More significantly, the new synthesis route reduces the use of hazardous chemicals, thus limiting the generation of hazardous waste during industrial production. This research offers significant potential for environmental pollution control.
UR - http://www.scopus.com/inward/record.url?scp=85170381995&partnerID=8YFLogxK
U2 - 10.1051/e3sconf/202340602033
DO - 10.1051/e3sconf/202340602033
M3 - Conference article
AN - SCOPUS:85170381995
SN - 2267-1242
VL - 406
JO - E3S Web of Conferences
JF - E3S Web of Conferences
M1 - 02033
T2 - 9th International Conference on Energy Materials and Environment Engineering, ICEMEE 2023
Y2 - 8 June 2023 through 10 June 2023
ER -