Green Synthesis of 7,8-Difluoro-6, 11-Dihydrodibenz[B,E]Thiophene-11-One of Baloxavir Marboxil - Reducing Environmental Pollution

Jiaru Wang, Mengdi Ru, Zihui Meng, Zhibing Xu*

*此作品的通讯作者

科研成果: 期刊稿件会议文章同行评审

摘要

Baloxavir marboxil is a novel anti-influenza drug with a unique mechanism of action that can effectively treat both type A and type B influenza. Key intermediate compound 7,8-difluoro-6,11-dihydrodibenz[b,e]thiophene-11-one is not only an important component of the chemical structure of baloxavir marboxil but also an essential intermediate in the synthetic route of the drug. However, conventional synthesis methods for key intermediate 7,8-difluoro-6,11-dihydrodibenz[b,e]thiophene-11-one usually utilize dangerous and harmful chemicals that can cause significant environmental pollution during large-scale production. This article proposes a new synthesis route for 7,8-difluoro-6,11-dihydrodibenz[b,e]thiophene-11-one to facilitate large-scale production while integrating the principles of green chemistry. This new route feature mild reaction conditions and simpler steps that result in an overall yield increase to 64.9%. More significantly, the new synthesis route reduces the use of hazardous chemicals, thus limiting the generation of hazardous waste during industrial production. This research offers significant potential for environmental pollution control.

源语言英语
文章编号02033
期刊E3S Web of Conferences
406
DOI
出版状态已出版 - 31 7月 2023
活动9th International Conference on Energy Materials and Environment Engineering, ICEMEE 2023 - Virtual, Online, 马来西亚
期限: 8 6月 202310 6月 2023

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