Default mode network in healthy elders: A pilot research on independent component analysis combined with correlation analysis

Objective: To investigate the consistency between independent component analysis (ICA) and correlation analysis of default mode network (DMN) in healthy elderly. Methods: Resting-state fMR examination was performed with 3.0T MR scanner and 8-channel head coil. After pre-process of fMRI data with SPM, ICA was performed with GIFT and correlation analysis was performed with AFNI. Functional areas of DMN in healthy elderly were compared between the two methods. Results: Except for hippocampal formation, consistent results of DMN were observed between ICA and correlation analysis. Functional connectivity was found between posterior cingulated cortex (PCC) and most of the functional areas in DMN. Conclusion: ICA and correlation analysis has consistent results for DMN. Combination of these two methods may contribute to the further study of brain function on resting-state fMRI.