@article{c50fda0fa3dd4d66a1b45464d0649f62,
title = "Chiral Squaramide Catalyzed Asymmetric [3+2] Cycloaddition Reaction for Synthesis of Trifluoromethylated Barbituric Acid Derivatives",
abstract = "A squaramide catalyzed asymmetric Michael/Mannich [3+2] cycloaddition reaction between N-2,2,2-trifluoroethyl isatin ketimines and barbiturate-based olefins was developed. The corresponding trifluoromethylated dispirobarbituric acid derivatives containing three stereocenters were obtained in excellent yields and stereoselectivities (up to 99% yield, 99:1 dr and >99% ee). In addition, the gram-scale reaction also achieved with excellent yield and stereoselectivity.",
keywords = "Cycloaddition, Squaramide, asymmetric catalysis, organocatalysis, spirobarbituric acids",
author = "An, {Tian Li} and Du, {Da Ming}",
note = "Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2019",
month = oct,
day = "17",
doi = "10.1002/slct.201903146",
language = "English",
volume = "4",
pages = "11302--11306",
journal = "ChemistrySelect",
issn = "2365-6549",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "38",
}