TY - GEN
T1 - Automated construction system for cellular tissue based on laminar flow fibers
AU - Kojima, Masaru
AU - Fukushima, Akira
AU - Takata, Suguru
AU - Horade, Mitsuhiro
AU - Ohara, Kenichi
AU - Sakai, Shinji
AU - Kamiyama, Kazuto
AU - Mae, Yasushi
AU - Arai, Tatsuo
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Cell tissue construction is one of the important issues for tissue engineering, which is a key-technology in regenerative medicine. Recently, several studies have reported, the in vitro fabrication of simple cell tissues. However, organs are made of some kinds of cells and they are complex tissues. Therefore, a technology to reproduce the complex structure and biological function of the organ is needed. In this paper, we propose an automated system for the construction of a cell tissue in vitro, based on hydrogel fiber. We fabricate the cell tissues with some kinds of gel fibers, and the tissues with fine arbitrary shape structures. To evaluate the proposed system, a fine lattice structure was constructed as an example of cell tissue form. Furthermore, we designed a gel fiber discharge nozzle using laminar flow, and fabricated the lattice structure using laminar flow fiber. Through the experiments of the lattice shape structure construction, we observed the cell growth in the constructed lattice form, which proves the functionality of the structure. Moreover, we fabricated 3-laminar flow fibers, and we will fabricate more functional cell tissues.
AB - Cell tissue construction is one of the important issues for tissue engineering, which is a key-technology in regenerative medicine. Recently, several studies have reported, the in vitro fabrication of simple cell tissues. However, organs are made of some kinds of cells and they are complex tissues. Therefore, a technology to reproduce the complex structure and biological function of the organ is needed. In this paper, we propose an automated system for the construction of a cell tissue in vitro, based on hydrogel fiber. We fabricate the cell tissues with some kinds of gel fibers, and the tissues with fine arbitrary shape structures. To evaluate the proposed system, a fine lattice structure was constructed as an example of cell tissue form. Furthermore, we designed a gel fiber discharge nozzle using laminar flow, and fabricated the lattice structure using laminar flow fiber. Through the experiments of the lattice shape structure construction, we observed the cell growth in the constructed lattice form, which proves the functionality of the structure. Moreover, we fabricated 3-laminar flow fibers, and we will fabricate more functional cell tissues.
KW - 3D cellular system assembly
KW - gel fibers
KW - laminar flow
UR - http://www.scopus.com/inward/record.url?scp=84991273741&partnerID=8YFLogxK
U2 - 10.1109/ICMA.2016.7558685
DO - 10.1109/ICMA.2016.7558685
M3 - Conference contribution
AN - SCOPUS:84991273741
T3 - 2016 IEEE International Conference on Mechatronics and Automation, IEEE ICMA 2016
SP - 920
EP - 925
BT - 2016 IEEE International Conference on Mechatronics and Automation, IEEE ICMA 2016
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 13th IEEE International Conference on Mechatronics and Automation, IEEE ICMA 2016
Y2 - 7 August 2016 through 10 August 2016
ER -