TY - GEN
T1 - Analysis of gray matter in AD patients and MCI subjects based voxel-based morphometry
AU - Yao, Zhijun
AU - Hu, Bin
AU - Zhao, Lina
AU - Liang, Chuanjiang
PY - 2011
Y1 - 2011
N2 - In recent years, pathological researches of mild cognitive impairment (MCI) subjects and the Alzheimer's disease (AD) patients have gained a great deal of attention. In this study, we used the voxel-based morphometry (VBM) method to analyze the Magnatic Resonance Imaging (MRI) data of gray matter volumes in 98 normal controls (NCs), 91 AD patients and 113 MCI subjects. The measurements of gray matter volumes were calculated for each of the three groups respectively. We found that compared with MCI subjects, AD patients had further atrophy in the following brain regions: right insula, left hippocampus, right fusiform and bilateral middle temporal gyrus. Compared with NCs, AD patients and MCI subjects shared some abnormal brain regions such as bilateral parahippocampal gyrus, bilateral hippocampus, left amygdala and left fusiform. The results provided additional evidences to support the viewpoint that MCI is the transitional stage between normal aging and AD.
AB - In recent years, pathological researches of mild cognitive impairment (MCI) subjects and the Alzheimer's disease (AD) patients have gained a great deal of attention. In this study, we used the voxel-based morphometry (VBM) method to analyze the Magnatic Resonance Imaging (MRI) data of gray matter volumes in 98 normal controls (NCs), 91 AD patients and 113 MCI subjects. The measurements of gray matter volumes were calculated for each of the three groups respectively. We found that compared with MCI subjects, AD patients had further atrophy in the following brain regions: right insula, left hippocampus, right fusiform and bilateral middle temporal gyrus. Compared with NCs, AD patients and MCI subjects shared some abnormal brain regions such as bilateral parahippocampal gyrus, bilateral hippocampus, left amygdala and left fusiform. The results provided additional evidences to support the viewpoint that MCI is the transitional stage between normal aging and AD.
KW - Alzheimer's disease
KW - mild cognitive impairment
KW - voxel-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=80052802825&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-23605-1_22
DO - 10.1007/978-3-642-23605-1_22
M3 - Conference contribution
AN - SCOPUS:80052802825
SN - 9783642236044
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 209
EP - 217
BT - Brain Informatics - International Conference, BI 2011, Proceedings
T2 - 2011 International Conference on Brain Informatics, BI 2011
Y2 - 7 September 2011 through 9 September 2011
ER -