TY - JOUR
T1 - An AIEE polyelectrolyte as a light-up fluorescent probe for heparin sensing in full detection range
AU - Chen, Dongyang
AU - Shi, Jianbing
AU - Wu, Yanmei
AU - Tong, Bin
AU - Zhi, Junge
AU - Dong, Yuping
PY - 2013/9
Y1 - 2013/9
N2 - Polyelectrolyte PTPEPyH, containing tetraphenylethene (TPE) and pyridinium, was synthesized. Its optical properties were investigated with spectroscopies and the results showed that there were two emission-enhanced stages in the interaction between positive-charged PTPEPyH and negative-charged biomacromolecule heparin. The mechanism was very different due to the reduced non-radiative energy loss and the change of surroundings. The polyelectrolyte PTPEPyH, compared with ChS and HA, also showed high selectivity for heparin in the buffer solution and could be used as a potential bio-probe for heparin quantification in the clinical full range.
AB - Polyelectrolyte PTPEPyH, containing tetraphenylethene (TPE) and pyridinium, was synthesized. Its optical properties were investigated with spectroscopies and the results showed that there were two emission-enhanced stages in the interaction between positive-charged PTPEPyH and negative-charged biomacromolecule heparin. The mechanism was very different due to the reduced non-radiative energy loss and the change of surroundings. The polyelectrolyte PTPEPyH, compared with ChS and HA, also showed high selectivity for heparin in the buffer solution and could be used as a potential bio-probe for heparin quantification in the clinical full range.
KW - aggregation-induced emission enhancement (AIEE)
KW - biosensor
KW - heparin quantification
KW - pyridinium
KW - tetraphenylethene (TPE)
UR - http://www.scopus.com/inward/record.url?scp=84883458737&partnerID=8YFLogxK
U2 - 10.1007/s11426-013-4915-8
DO - 10.1007/s11426-013-4915-8
M3 - Article
AN - SCOPUS:84883458737
SN - 1674-7291
VL - 56
SP - 1239
EP - 1246
JO - Science China Chemistry
JF - Science China Chemistry
IS - 9
ER -