Advances of Microfluidic Technologies Applied in Bio-analytical Chemistry

Compared with conventional analysis system, microfluidics-based analysis system has many advantages, such as low consumption of sample and reagent, high efficiency in mass and heat transfer, good biocompatibility, high-throughput parallel analysis, as well as its integration, miniaturization and automation. It has been widely applied in the analytical chemistry, especially in the field of bio-analytical chemistry. In this review, we mainly focused on the progress of microfluidic technologies for cellular application during the past five years, such as the chip material and fabrication, surface modification and droplet techniques. Then we briefly summarized the applications of microfluidic techniques in drug screening and cellular analysis.