摘要
Herein, a novel kind of intelligent nanogels have been designed, which can spatiotemporally control the release of drug (doxorubicin) and photosensitizers (porphyrins) to combine chemo-therapy and photodynamic therapy. Further, the fluorescing properties of porphyrins make it possible to be used as a kind of diagnostic bio-imaging agents. In vitro release assays confirm that DOX-loaded nanogels show obvious intracellular pH-sensitive property. The intracellular experiments further prove that drug-loaded nanogels has the significantly antitumor efficacy due to the combination of chemotherapy and photodynamic therapy, which made this drug delivery system hold great potential applications for further cancer treatment. A novel kind of intelligent nanogels is designed, which can spatiotemporally control the release of drug (doxorubicin) and photosensitizers (porphyrins) to combine chemo-therapy and photodynamic therapy.
源语言 | 英语 |
---|---|
页(从-至) | 1563-1570 |
页数 | 8 |
期刊 | Macromolecular Bioscience |
卷 | 15 |
期 | 11 |
DOI | |
出版状态 | 已出版 - 1 11月 2015 |
已对外发布 | 是 |