Acid-Sensitive Nanogels for Synergistic Chemo-Photodynamic Therapy

Xiaofei Chen, Xuemei Yao, Li Chen*, Xuesi Chen

*此作品的通讯作者

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14 引用 (Scopus)

摘要

Herein, a novel kind of intelligent nanogels have been designed, which can spatiotemporally control the release of drug (doxorubicin) and photosensitizers (porphyrins) to combine chemo-therapy and photodynamic therapy. Further, the fluorescing properties of porphyrins make it possible to be used as a kind of diagnostic bio-imaging agents. In vitro release assays confirm that DOX-loaded nanogels show obvious intracellular pH-sensitive property. The intracellular experiments further prove that drug-loaded nanogels has the significantly antitumor efficacy due to the combination of chemotherapy and photodynamic therapy, which made this drug delivery system hold great potential applications for further cancer treatment. A novel kind of intelligent nanogels is designed, which can spatiotemporally control the release of drug (doxorubicin) and photosensitizers (porphyrins) to combine chemo-therapy and photodynamic therapy.

源语言英语
页(从-至)1563-1570
页数8
期刊Macromolecular Bioscience
15
11
DOI
出版状态已出版 - 1 11月 2015
已对外发布

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