TY - GEN
T1 - Abnormal neural activity and functional connectivity in amnestic Mild cognitive impairmet
T2 - 2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
AU - Liu, Ruiyue
AU - Hu, Bin
AU - Yao, Zhijun
AU - Ratcliffe, Martyn
AU - Wang, Wei
AU - Liang, Chuanjiang
AU - Cai, Qingcui
AU - Yang, Jing
AU - Zhao, Qinglin
PY - 2013
Y1 - 2013
N2 - Mild cognitive impairment (MCI) is a brain-function syndrome involving the onset and evolution of cognitive impairments which are not significant enough to interfere with daily activities. In this study, we used resting state functional magnetic resonance imaging (fMRI) to detect the whole brain fractional amplitude of low-frequency fluctuations (fALFF) and functional connectivity in 32 amnestic MCI subjects (aMCIs) and 28 healthy elderly normal controls (NCs). Compared to NCs, aMCIs showed significant decreases of fALFF value in right inferior temporal gyrus, left inferior occipital gyrus and left postcentral gyrus, while increases were found mainly in the right lingual and precunues. The functional connectivity decreased in the regions of left dorsolateral superior frontal gyrus, the right orbital frontal gyrus and left inferior temporal gyrus. These findings may be helpful to understand the pathophysiological mechanism of mild cognitive impairment.
AB - Mild cognitive impairment (MCI) is a brain-function syndrome involving the onset and evolution of cognitive impairments which are not significant enough to interfere with daily activities. In this study, we used resting state functional magnetic resonance imaging (fMRI) to detect the whole brain fractional amplitude of low-frequency fluctuations (fALFF) and functional connectivity in 32 amnestic MCI subjects (aMCIs) and 28 healthy elderly normal controls (NCs). Compared to NCs, aMCIs showed significant decreases of fALFF value in right inferior temporal gyrus, left inferior occipital gyrus and left postcentral gyrus, while increases were found mainly in the right lingual and precunues. The functional connectivity decreased in the regions of left dorsolateral superior frontal gyrus, the right orbital frontal gyrus and left inferior temporal gyrus. These findings may be helpful to understand the pathophysiological mechanism of mild cognitive impairment.
UR - http://www.scopus.com/inward/record.url?scp=84897691434&partnerID=8YFLogxK
U2 - 10.1109/NER.2013.6696047
DO - 10.1109/NER.2013.6696047
M3 - Conference contribution
AN - SCOPUS:84897691434
SN - 9781467319690
T3 - International IEEE/EMBS Conference on Neural Engineering, NER
SP - 765
EP - 769
BT - 2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
Y2 - 6 November 2013 through 8 November 2013
ER -