A novel and efficient synthesis of 3'-amino-3'-deoxyadenosine

Wei Chen*, Xin Ming Qian, Xue Qiu He, Tao Peng

*此作品的通讯作者

科研成果: 书/报告/会议事项章节会议稿件同行评审

摘要

A novel method for efficient synthesis of 3'-amino-3'-deoxyadenosine from adenosine was developed. Adenosine was reacted with triethyl orthoacetate and then acetyl bromide to afford 2', 5'-O-acetyl-3'-bromo-3'-deoxyadenosine, which reacted with N-benzyl-4-nitrobenzenesulfonamide and then with thiophenol to yield 3'-(benzylamino)-3'-deoxy-adenosine. Following treated with Pd/C and H2, 3'-amino-3'-deoxyadenosine was synthesized. This method was facile and efficient.

源语言英语
主期刊名2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Proceedings
7318-7321
页数4
DOI
出版状态已出版 - 2011
活动2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Nanjing, 中国
期限: 24 6月 201126 6月 2011

出版系列

姓名2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Proceedings

会议

会议2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011
国家/地区中国
Nanjing
时期24/06/1126/06/11

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