A micro channel device for biomechanical analysis to apply a mechanical stimulus on large number of cells

Masahiro Totani, Masaru Kojima, Mitsuhiro Horade, Kazuto Kamiyama, Yasushi Mae, Toshihiko Ogura, Makoto Kaneko, Tatsuo Arai

科研成果: 书/报告/会议事项章节会议稿件同行评审

摘要

Many researches have reported that the mechanical stimulus is important factor of the histogenesis and cellular differentiation. However, it is not clearly understood for cellular nucleus how to respond to the mechanical stimulus. Our purpose is applying a mechanical stimulus to cells for gene expression assay. On this paper, we report development of a micro-channel device and evaluating the device by observation. This device is designed to have a low-height channel and cells are pressed when passing through that channel. In experiment, we succeed in observing that cells and nucleuses are deformed in the channel. In addition, 2.0 × 104 cells are collected from this device.

源语言英语
主期刊名2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016
出版商Institute of Electrical and Electronics Engineers Inc.
ISBN(电子版)9781509027842
DOI
出版状态已出版 - 18 1月 2017
已对外发布
活动27th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016 - Nagoya, 日本
期限: 28 11月 201630 11月 2016

出版系列

姓名2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016

会议

会议27th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016
国家/地区日本
Nagoya
时期28/11/1630/11/16

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引用此

Totani, M., Kojima, M., Horade, M., Kamiyama, K., Mae, Y., Ogura, T., Kaneko, M., & Arai, T. (2017). A micro channel device for biomechanical analysis to apply a mechanical stimulus on large number of cells. 在 2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016 文章 7824190 (2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MHS.2016.7824190