A colorimetric and ratiometric fluorescent probe for quantitative detection of GSH at physiologically relevant levels

Xiaodan Zeng; Xiaoling Zhang; Baocun Zhu; Hongying Jia; Wen Yang; Yamin Li; Juan Xue

doi:10.1016/j.snb.2011.06.062

A colorimetric and ratiometric fluorescent probe for quantitative detection of GSH at physiologically relevant levels

Xiaodan Zeng, Xiaoling Zhang^*, Baocun Zhu, Hongying Jia, Wen Yang, Yamin Li, Juan Xue

^*此作品的通讯作者

化学与化工学院

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46 引用（Scopus）

摘要

A naphthalene derivate containing piazselenole (NDP) has been developed as an example of colorimetric and ratiometric fluorescent probes for glutathione (GSH) at physiologically relevant concentration. Upon addition of GSH, the probe displayed a ratiometric fluorescent response with an enhancement of the ratios of emission intensities at 436 and 615 nm, accompanied with the solution color change from jacinth to colorlessness. The detection range is 0-80 mM with the detection limit of 0.178 mM. Moreover, the probe showed good selectivity and satisfying results in the determination of GSH. As the linear response range covers the concentration range of biological samples, the probe may have the potential to determine GSH directly in biological samples in the future.

源语言	英语
页（从-至）	142-147
页数	6
期刊	Sensors and Actuators, B: Chemical
卷	159
期	1
DOI	https://doi.org/10.1016/j.snb.2011.06.062
出版状态	已出版 - 28 11月 2011

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title = "A colorimetric and ratiometric fluorescent probe for quantitative detection of GSH at physiologically relevant levels",

abstract = "A naphthalene derivate containing piazselenole (NDP) has been developed as an example of colorimetric and ratiometric fluorescent probes for glutathione (GSH) at physiologically relevant concentration. Upon addition of GSH, the probe displayed a ratiometric fluorescent response with an enhancement of the ratios of emission intensities at 436 and 615 nm, accompanied with the solution color change from jacinth to colorlessness. The detection range is 0-80 mM with the detection limit of 0.178 mM. Moreover, the probe showed good selectivity and satisfying results in the determination of GSH. As the linear response range covers the concentration range of biological samples, the probe may have the potential to determine GSH directly in biological samples in the future.",

keywords = "Colorimetric, Glutathione (GSH), Piazselenole, Probe, Ratiometric fluorescent",

author = "Xiaodan Zeng and Xiaoling Zhang and Baocun Zhu and Hongying Jia and Wen Yang and Yamin Li and Juan Xue",

year = "2011",

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T1 - A colorimetric and ratiometric fluorescent probe for quantitative detection of GSH at physiologically relevant levels

AU - Zeng, Xiaodan

AU - Zhang, Xiaoling

AU - Zhu, Baocun

AU - Jia, Hongying

AU - Yang, Wen

AU - Li, Yamin

AU - Xue, Juan

PY - 2011/11/28

Y1 - 2011/11/28

N2 - A naphthalene derivate containing piazselenole (NDP) has been developed as an example of colorimetric and ratiometric fluorescent probes for glutathione (GSH) at physiologically relevant concentration. Upon addition of GSH, the probe displayed a ratiometric fluorescent response with an enhancement of the ratios of emission intensities at 436 and 615 nm, accompanied with the solution color change from jacinth to colorlessness. The detection range is 0-80 mM with the detection limit of 0.178 mM. Moreover, the probe showed good selectivity and satisfying results in the determination of GSH. As the linear response range covers the concentration range of biological samples, the probe may have the potential to determine GSH directly in biological samples in the future.

AB - A naphthalene derivate containing piazselenole (NDP) has been developed as an example of colorimetric and ratiometric fluorescent probes for glutathione (GSH) at physiologically relevant concentration. Upon addition of GSH, the probe displayed a ratiometric fluorescent response with an enhancement of the ratios of emission intensities at 436 and 615 nm, accompanied with the solution color change from jacinth to colorlessness. The detection range is 0-80 mM with the detection limit of 0.178 mM. Moreover, the probe showed good selectivity and satisfying results in the determination of GSH. As the linear response range covers the concentration range of biological samples, the probe may have the potential to determine GSH directly in biological samples in the future.

KW - Colorimetric

KW - Glutathione (GSH)

KW - Piazselenole

KW - Probe

KW - Ratiometric fluorescent

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A colorimetric and ratiometric fluorescent probe for quantitative detection of GSH at physiologically relevant levels

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