A Bacteriochlorin-Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging-Guided Highly Efficient Photodynamic Therapy

Kai Zhang, Zhaofeng Yu, Xiangdan Meng*, Weidong Zhao, Zhuojie Shi, Zhou Yang, Haifeng Dong, Xueji Zhang

*此作品的通讯作者

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143 引用 (Scopus)

摘要

Hypoxic tumor microenvironment is the bottleneck of the conventional photodynamic therapy (PDT) and significantly weakens the overall therapeutic efficiency. Herein, versatile metal–organic framework (MOF) nanosheets (DBBC-UiO) comprised of bacteriochlorin ligand and Hf63-O)43-OH)4 clusters to address this tricky issue are designed. The resulting DBBC-UiO enables numerous superoxide anion radical (O2−•) generation via a type I mechanism with a 750 nm NIR-laser irradiation, part of which transforms to high toxic hydroxyl radical (OH•) and oxygen (O2) through superoxide dismutase (SOD)-mediated catalytic reactions under severe hypoxic microenvironment (2% O2), and the partial recycled O2 enhances O2−• generation. Owing to the synergistic radicals, it realizes advanced antitumor performance with 91% cell mortality against cancer cells in vitro, and highly efficient hypoxic solid tumor ablation in vivo. It also accomplishes photoacoustic imaging (PAI) for cancer diagnosis. This DBBC-UiO, taking advantage of superb penetration depth of the 750 nm laser and distinct antihypoxia activities, offers new opportunities for PDT against clinically hypoxic cancer.

源语言英语
文章编号1900530
期刊Advanced Science
6
14
DOI
出版状态已出版 - 17 7月 2019
已对外发布

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Zhang, K., Yu, Z., Meng, X., Zhao, W., Shi, Z., Yang, Z., Dong, H., & Zhang, X. (2019). A Bacteriochlorin-Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging-Guided Highly Efficient Photodynamic Therapy. Advanced Science, 6(14), 文章 1900530. https://doi.org/10.1002/advs.201900530