铁死亡在胶质瘤治疗领域的作用

Erastin causes ferroptosis (this form of iron-dependent cell death is distinct from apoptosis, necroptosis, and autophagy) by inhibiting the activity of SLC7A11 to acquire cystine/glutamate. However, the molecular mechanism of iron death regulation remains largely unknown. Studying the effects of ferroptosis on glial cells plays an important role in the treatment of glioma. The cells of the dosing group and the cells after irradiation were counted by MTS method and MILLIPORE Scepter hand-held automated cell counter, respectively. Wild type glioma cells U87MG and P53 mutant glioma cells U251MG were cultured with different concentrations of Erastin. Analysis results show that, the U87MG is sensitive to Erastin. Besides, Gamma rays can not further promote the ferroptosis caused by Erastin. Traditional Chinese medicine Dragon Blood with anti-oxidation can effectively inhibit ferroptosis caused by Erastin. In summary, the Erastin can play an important role in the field of glioma chemotherapy, and the Dragon's blood can play an important role in inhibiting iron death and protecting healthy cells.