血流动力学响应函数在脑疾病中的研究进展

Hemodynamic response function (HRF) which is a mathematical transfer function between neural activity and functional magnetic resonance imaging (fMRI) is related to neurovascular physiology and carries a lot of information related to brain function and pathology of brain diseases which can't be obtained by traditional fMRI analysis. Herein the advances in HRF are reviewed. A basic introduction to fMRI and HRF is given, mainly focusing on 3 parameters of HRF, namely response height, time-to-peak and full-width at half-max. Then, a deconvolution method to estimate HRF parameters is introduced, and the research status of HRF related to the pathology of brain diseases in recent years is summarized. It is found that HRF is associated with the pathology of brain diseases such as obsessive-compulsive disorder, autism spectrum disorder, post-traumatic stress disorder and brain injuries. Modeling and parameters extraction of HRF can provide more potential neuropathological information. HRF analysis can be used as a window for pathological study of brain diseases and provides a new perspective and method for traditional fMRI analysis.