磺酸树脂催化合成对叔丁基苯甲酸甲酯的研究

Methyl 4-tert-butylbenzoate (MPTBBA) is an important intermediate in the pharmaceutical industry and organic synthesis applications.But most of the traditional synthesis methods for MPTBBA have the shortcomings in separation and corrosion.Sulfonic acid type ion exchange resin catalyst is used in catalytic synthesis of MPTBBA, the effects of resin types, reaction temperature, catalyst dosage and raw materials ratio on the catalytic performance of the catalyst are investigated.Among all catalysts, D001 sulfonic acid resin catalyst exhibits the best catalytic performance.The conversion rate of p-tert-butylbenzoic acid (PTBBA) can reach 90% after 3 h by using D001 sulfonic acid resin as catalyst when reaction temperature remains at 120^oC, the molar ratio of methanol to PTBBA is 8:1 and catalyst dosage is 10 wt.%.It is found through characterization that sulfonic acid resin catalysts possesses good thermal stability in the reaction, and their catalytic performance depends on their acid amount.The catalyst with higher acid amount exhibits better catalytic performance. The sulfonic acid resin catalysts can be separated from the products conveniently and maintains stable high catalytic performance after 6 cycles of use, which shows a promising prospect in industrial application of MPTBBA synthesis.