Two new cyclic depsipeptides from the endophytic fungus fusarium sp.

Fang Lv; Georgios Daletos; Wenhan Lin; Peter Proksch

doi:10.1177/1934578x1501001011

Two new cyclic depsipeptides from the endophytic fungus fusarium sp.

Fang Lv, Georgios Daletos, Wenhan Lin, Peter Proksch

School of Life Science

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Two new cyclic depsipeptides, W493 C (1) and D (2), along with two known derivatives W493 A (3) and B (4) were obtained from the endophytic fungus Fusarium sp. isolated from the Mangrove plant Ceriops tagal. The structures of the new compounds were determined on the basis of one- and two dimensional NMR and high-resolution mass spectroscopic data. The absolute configurations of the amino acid residues of 1 and 2 were confirmed by application of Marfey's method. W493 A (3) and B (4) exhibited moderate activity against the fungus Cladosporium cladosporiodes and weak antitumor activity against the human ovarian cancer cell line A2780.

Original language	English
Pages (from-to)	1667-1670
Number of pages	4
Journal	Natural Product Communications
Volume	10
Issue number	10
DOIs	https://doi.org/10.1177/1934578x1501001011
Publication status	Published - Oct 2015

Keywords

Cyclic depsipeptides
Endophyte
Fusarium sp.
Structure elucidation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1934578x1501001011

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abstract = "Two new cyclic depsipeptides, W493 C (1) and D (2), along with two known derivatives W493 A (3) and B (4) were obtained from the endophytic fungus Fusarium sp. isolated from the Mangrove plant Ceriops tagal. The structures of the new compounds were determined on the basis of one- and two dimensional NMR and high-resolution mass spectroscopic data. The absolute configurations of the amino acid residues of 1 and 2 were confirmed by application of Marfey's method. W493 A (3) and B (4) exhibited moderate activity against the fungus Cladosporium cladosporiodes and weak antitumor activity against the human ovarian cancer cell line A2780.",

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author = "Fang Lv and Georgios Daletos and Wenhan Lin and Peter Proksch",

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AU - Lv, Fang

AU - Daletos, Georgios

AU - Lin, Wenhan

AU - Proksch, Peter

PY - 2015/10

Y1 - 2015/10

N2 - Two new cyclic depsipeptides, W493 C (1) and D (2), along with two known derivatives W493 A (3) and B (4) were obtained from the endophytic fungus Fusarium sp. isolated from the Mangrove plant Ceriops tagal. The structures of the new compounds were determined on the basis of one- and two dimensional NMR and high-resolution mass spectroscopic data. The absolute configurations of the amino acid residues of 1 and 2 were confirmed by application of Marfey's method. W493 A (3) and B (4) exhibited moderate activity against the fungus Cladosporium cladosporiodes and weak antitumor activity against the human ovarian cancer cell line A2780.

AB - Two new cyclic depsipeptides, W493 C (1) and D (2), along with two known derivatives W493 A (3) and B (4) were obtained from the endophytic fungus Fusarium sp. isolated from the Mangrove plant Ceriops tagal. The structures of the new compounds were determined on the basis of one- and two dimensional NMR and high-resolution mass spectroscopic data. The absolute configurations of the amino acid residues of 1 and 2 were confirmed by application of Marfey's method. W493 A (3) and B (4) exhibited moderate activity against the fungus Cladosporium cladosporiodes and weak antitumor activity against the human ovarian cancer cell line A2780.

KW - Cyclic depsipeptides

KW - Endophyte

KW - Fusarium sp.

KW - Structure elucidation

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ER -

Two new cyclic depsipeptides from the endophytic fungus fusarium sp.

Abstract

Keywords

UN SDGs

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