Triazole-gold (TAAu) catalyzed three-component coupling (A3 reaction) towards the synthesis of 2, 4-disubstituted quinoline derivatives

Fusong Zhang, Qi Lai, Xiaodong Shi*, Zhiguang Song

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

A gold-catalyzed three-component coupling reaction (A3 reaction) was developed as an efficient approach for the synthesis of challenging 2, 4-disubstituted quinoline derivatives. Compared to previously reported Cu/Au bi-catalyst system, this protocol enables achieving A3 reaction only in the presence of triazole-gold catalyst. Notably, 4-alkyl substituted or 2-alkyl substituted quinoline derivatives were obtained with good yields, which highlighted the unique advantage of this new strategy.

Original languageEnglish
Pages (from-to)392-394
Number of pages3
JournalChinese Chemical Letters
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 2019
Externally publishedYes

Keywords

  • A3 reaction
  • Gold catalysis
  • Quinoline
  • Triazole-gold

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