@inproceedings{5d59e02eaf3142c4bad82cc42b691ede,
title = "Thrombolysis enhanced by dual-frequency highintensity focused ultrasound",
abstract = "It has been demonstrated that high-intensity focused ultrasound can be an efficient method to induce thrombolysis. Excessive thermal effect on neighboring tissue is however a concern. The goal of this work is to test the efficacy of dual-frequency ultrasound-induced thrombolysis, with the aim to reduce the acoustic power required to achieve the same lysis rate (mass loss of blood clots over time) as single-frequency ultrasound. In vitro clots of mouse blood were prepared and placed at the focus of two piezoelectric ultrasound transducers (center frequencies were 0.95 MHz and 1.5 MHz, respectively). 0.65 W ultrasound waves with 10% duty cycle were employed in both single- and dual-frequency ultrasound exposures. The mass losses of the clots were recorded to obtain the lysis rate after each test. It was found that dual-frequency results in more efficient thrombolysis. Cavitation bubble modeling was also conducted for both single- and dual-frequency ultrasound to explain the experimental founding.",
keywords = "cavitation, dual-frequency ultrasound, high-intensity focused ultrasound (HIFU), thrombolysis",
author = "Sijia Guo and Dingjie Suo and Yun Jing and Xiaoning Jiang and Jonathan Frank and Weili Lin",
note = "Publisher Copyright: {\textcopyright} 2014 IEEE.; 2014 IEEE International Ultrasonics Symposium, IUS 2014 ; Conference date: 03-09-2014 Through 06-09-2014",
year = "2014",
month = oct,
day = "20",
doi = "10.1109/ULTSYM.2014.0541",
language = "English",
series = "IEEE International Ultrasonics Symposium, IUS",
publisher = "IEEE Computer Society",
pages = "2173--2176",
booktitle = "IEEE International Ultrasonics Symposium, IUS",
address = "United States",
}