The radioresistant and survival mechanisms of Deinococcus radiodurans

Feng Liu; Nuomin Li; Yongqian Zhang

doi:10.1016/j.radmp.2023.03.001

The radioresistant and survival mechanisms of Deinococcus radiodurans

Feng Liu, Nuomin Li, Yongqian Zhang^*

^*Corresponding author for this work

School of Medical and Technology

Beijing Institute of Technology

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

Deinococcus radiodurans (D. radiodurans) is distinguished by the most radioresistant organism ever known, and can tolerate extreme environments such as ionizing radiation, ultraviolet radiation, oxidation, and desiccation. D. radiodurans is an important model for studying DNA damage/repair and redox regulation upon high dose ionizing radiation. How D. radiodurans response and repair ROS-induced oxidative damage remains a subject of ongoing investigation. This review provides an overview of the radioresistance characteristics of D. radiodurans. Among them, the DNA damage repair pathway and high-efficiency antioxidant defense system are summarized in detail. Furthermore, a novel model that protects the cell against the ionizing radiation is proposed. This review also discusses the potential application, future challenges and directions in advancing towards D. radiodurans studies.

Original language	English
Pages (from-to)	70-79
Number of pages	10
Journal	Radiation Medicine and Protection
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/j.radmp.2023.03.001
Publication status	Published - Jun 2023

Keywords

Antioxidant defense system
DNA repair
Deinococcus radiodurans
Oxidative stress
Radioresistant mechanism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.radmp.2023.03.001

Cite this

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title = "The radioresistant and survival mechanisms of Deinococcus radiodurans",

abstract = "Deinococcus radiodurans (D. radiodurans) is distinguished by the most radioresistant organism ever known, and can tolerate extreme environments such as ionizing radiation, ultraviolet radiation, oxidation, and desiccation. D. radiodurans is an important model for studying DNA damage/repair and redox regulation upon high dose ionizing radiation. How D. radiodurans response and repair ROS-induced oxidative damage remains a subject of ongoing investigation. This review provides an overview of the radioresistance characteristics of D. radiodurans. Among them, the DNA damage repair pathway and high-efficiency antioxidant defense system are summarized in detail. Furthermore, a novel model that protects the cell against the ionizing radiation is proposed. This review also discusses the potential application, future challenges and directions in advancing towards D. radiodurans studies.",

keywords = "Antioxidant defense system, DNA repair, Deinococcus radiodurans, Oxidative stress, Radioresistant mechanism",

author = "Feng Liu and Nuomin Li and Yongqian Zhang",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = jun,

doi = "10.1016/j.radmp.2023.03.001",

language = "English",

volume = "4",

pages = "70--79",

journal = "Radiation Medicine and Protection",

issn = "2097-0439",

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TY - JOUR

T1 - The radioresistant and survival mechanisms of Deinococcus radiodurans

AU - Liu, Feng

AU - Li, Nuomin

AU - Zhang, Yongqian

PY - 2023/6

Y1 - 2023/6

N2 - Deinococcus radiodurans (D. radiodurans) is distinguished by the most radioresistant organism ever known, and can tolerate extreme environments such as ionizing radiation, ultraviolet radiation, oxidation, and desiccation. D. radiodurans is an important model for studying DNA damage/repair and redox regulation upon high dose ionizing radiation. How D. radiodurans response and repair ROS-induced oxidative damage remains a subject of ongoing investigation. This review provides an overview of the radioresistance characteristics of D. radiodurans. Among them, the DNA damage repair pathway and high-efficiency antioxidant defense system are summarized in detail. Furthermore, a novel model that protects the cell against the ionizing radiation is proposed. This review also discusses the potential application, future challenges and directions in advancing towards D. radiodurans studies.

AB - Deinococcus radiodurans (D. radiodurans) is distinguished by the most radioresistant organism ever known, and can tolerate extreme environments such as ionizing radiation, ultraviolet radiation, oxidation, and desiccation. D. radiodurans is an important model for studying DNA damage/repair and redox regulation upon high dose ionizing radiation. How D. radiodurans response and repair ROS-induced oxidative damage remains a subject of ongoing investigation. This review provides an overview of the radioresistance characteristics of D. radiodurans. Among them, the DNA damage repair pathway and high-efficiency antioxidant defense system are summarized in detail. Furthermore, a novel model that protects the cell against the ionizing radiation is proposed. This review also discusses the potential application, future challenges and directions in advancing towards D. radiodurans studies.

KW - Antioxidant defense system

KW - DNA repair

KW - Deinococcus radiodurans

KW - Oxidative stress

KW - Radioresistant mechanism

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U2 - 10.1016/j.radmp.2023.03.001

DO - 10.1016/j.radmp.2023.03.001

M3 - Review article

AN - SCOPUS:85150357063

SN - 2097-0439

VL - 4

SP - 70

EP - 79

JO - Radiation Medicine and Protection

JF - Radiation Medicine and Protection

IS - 2

ER -

The radioresistant and survival mechanisms of Deinococcus radiodurans

Abstract

Keywords

UN SDGs

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