The antithrombogenecity of silk fibroin films blending with citric acid and PVA

Jinghua Li; Chuanbao Cao; Xilan Ma; Yin Tang; Hesun Zhu

doi:10.4028/0-87849-967-9.417

The antithrombogenecity of silk fibroin films blending with citric acid and PVA

Jinghua Li, Chuanbao Cao^*, Xilan Ma, Yin Tang, Hesun Zhu

^*Corresponding author for this work

School of Material Science and Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The citric acid (CA) was added to the silk fibroin and Polyvinyl Alcohol (PVA) copolymer system. The blending 4% PVA was for improving the mechanical properties of the silk fibroin films. Citric acid amount varies from 0.5% to 2% of weight. The antithrombogenecity was characterized by in vitro clot time of prothrombin time (PT), the Activated partial thromboplastin time (APTT) and thrombin time (TT). The mechanical properties of the blending films were measured and the tensile strength and breaking elongation of films reached to 25.3MPa and 102%. The anticoagulant property results indicated that APTT and TT prolonged significantly, but PT has no effective change. We discussed the relationship between the structure and properties and proposed an anticoagulant mechanism.

Original language	English
Pages (from-to)	417-420
Number of pages	4
Journal	Key Engineering Materials
Volume	288-289
DOIs	https://doi.org/10.4028/0-87849-967-9.417
Publication status	Published - 2005

Keywords

Blending
Blood compatibility
Citric acid
PVA
Silk fibroin

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title = "The antithrombogenecity of silk fibroin films blending with citric acid and PVA",

abstract = "The citric acid (CA) was added to the silk fibroin and Polyvinyl Alcohol (PVA) copolymer system. The blending 4% PVA was for improving the mechanical properties of the silk fibroin films. Citric acid amount varies from 0.5% to 2% of weight. The antithrombogenecity was characterized by in vitro clot time of prothrombin time (PT), the Activated partial thromboplastin time (APTT) and thrombin time (TT). The mechanical properties of the blending films were measured and the tensile strength and breaking elongation of films reached to 25.3MPa and 102%. The anticoagulant property results indicated that APTT and TT prolonged significantly, but PT has no effective change. We discussed the relationship between the structure and properties and proposed an anticoagulant mechanism.",

keywords = "Blending, Blood compatibility, Citric acid, PVA, Silk fibroin",

author = "Jinghua Li and Chuanbao Cao and Xilan Ma and Yin Tang and Hesun Zhu",

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TY - JOUR

T1 - The antithrombogenecity of silk fibroin films blending with citric acid and PVA

AU - Li, Jinghua

AU - Cao, Chuanbao

AU - Ma, Xilan

AU - Tang, Yin

AU - Zhu, Hesun

PY - 2005

Y1 - 2005

N2 - The citric acid (CA) was added to the silk fibroin and Polyvinyl Alcohol (PVA) copolymer system. The blending 4% PVA was for improving the mechanical properties of the silk fibroin films. Citric acid amount varies from 0.5% to 2% of weight. The antithrombogenecity was characterized by in vitro clot time of prothrombin time (PT), the Activated partial thromboplastin time (APTT) and thrombin time (TT). The mechanical properties of the blending films were measured and the tensile strength and breaking elongation of films reached to 25.3MPa and 102%. The anticoagulant property results indicated that APTT and TT prolonged significantly, but PT has no effective change. We discussed the relationship between the structure and properties and proposed an anticoagulant mechanism.

AB - The citric acid (CA) was added to the silk fibroin and Polyvinyl Alcohol (PVA) copolymer system. The blending 4% PVA was for improving the mechanical properties of the silk fibroin films. Citric acid amount varies from 0.5% to 2% of weight. The antithrombogenecity was characterized by in vitro clot time of prothrombin time (PT), the Activated partial thromboplastin time (APTT) and thrombin time (TT). The mechanical properties of the blending films were measured and the tensile strength and breaking elongation of films reached to 25.3MPa and 102%. The anticoagulant property results indicated that APTT and TT prolonged significantly, but PT has no effective change. We discussed the relationship between the structure and properties and proposed an anticoagulant mechanism.

KW - Blending

KW - Blood compatibility

KW - Citric acid

KW - PVA

KW - Silk fibroin

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DO - 10.4028/0-87849-967-9.417

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SN - 1013-9826

VL - 288-289

SP - 417

EP - 420

JO - Key Engineering Materials

JF - Key Engineering Materials

ER -

The antithrombogenecity of silk fibroin films blending with citric acid and PVA

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Keywords

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