Synthesis and characterization of thermosensitive and supramolecular structured hydrogels

Hongliang Wei; Huaiqing Yu; Ai Ying Zhang; Ling Gang Sun; Dandan Hou; Zeng Guo Feng

doi:10.1021/ma050887p

Synthesis and characterization of thermosensitive and supramolecular structured hydrogels

Hongliang Wei, Huaiqing Yu, Ai Ying Zhang, Ling Gang Sun, Dandan Hou, Zeng Guo Feng^*

^*Corresponding author for this work

School of Material Science and Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

New kinds of thermosensitive and supramolecular structured hydrogels were synthesized via copolymerization of N-isopropylacrylamide (NIPA) with photocurable and biodegradable polypseudorotaxanes as cross-linkers under UV irradiation. The polypseudorotaxanes were prepared by supramolecular self-assemblies of α-cyclodextrins threaded onto amphiphilic LA-PEG-LA copolymers end-capped with methacryloyl groups. The structure of the hydrogels was characterized in detail with FTIR, ¹H NMR, XRD, DSC, and TGA techniques. The analytical results have demonstrated that the channel-type crystalline structure of inclusion complexes (ICs) remains in as-obtained hydrogels. Their swelling behavior was measured gravimetrically in the temperature range from 22 to 67 °C. It was observed that the crosslinked hydrogel made of only the macromer guest shows also thermosensitive. However, this stimuli-responsive property disappears when α-CDs are threaded onto the polymeric backbone and reappears when PNIPA blocks are introduced. The theromsensitivity of these hydrogels could be modulated by changing the PNIPA content as well as the α-CD to macromer ratio.

Original language	English
Pages (from-to)	8833-8839
Number of pages	7
Journal	Macromolecules
Volume	38
Issue number	21
DOIs	https://doi.org/10.1021/ma050887p
Publication status	Published - 18 Oct 2005

Access to Document

10.1021/ma050887p

Cite this

@article{05fcf35520894f58b90879582a0ea5a9,

title = "Synthesis and characterization of thermosensitive and supramolecular structured hydrogels",

abstract = "New kinds of thermosensitive and supramolecular structured hydrogels were synthesized via copolymerization of N-isopropylacrylamide (NIPA) with photocurable and biodegradable polypseudorotaxanes as cross-linkers under UV irradiation. The polypseudorotaxanes were prepared by supramolecular self-assemblies of α-cyclodextrins threaded onto amphiphilic LA-PEG-LA copolymers end-capped with methacryloyl groups. The structure of the hydrogels was characterized in detail with FTIR, 1H NMR, XRD, DSC, and TGA techniques. The analytical results have demonstrated that the channel-type crystalline structure of inclusion complexes (ICs) remains in as-obtained hydrogels. Their swelling behavior was measured gravimetrically in the temperature range from 22 to 67 °C. It was observed that the crosslinked hydrogel made of only the macromer guest shows also thermosensitive. However, this stimuli-responsive property disappears when α-CDs are threaded onto the polymeric backbone and reappears when PNIPA blocks are introduced. The theromsensitivity of these hydrogels could be modulated by changing the PNIPA content as well as the α-CD to macromer ratio.",

author = "Hongliang Wei and Huaiqing Yu and Zhang, {Ai Ying} and Sun, {Ling Gang} and Dandan Hou and Feng, {Zeng Guo}",

year = "2005",

month = oct,

day = "18",

doi = "10.1021/ma050887p",

language = "English",

volume = "38",

pages = "8833--8839",

journal = "Macromolecules",

issn = "0024-9297",

publisher = "American Chemical Society",

number = "21",

}

TY - JOUR

T1 - Synthesis and characterization of thermosensitive and supramolecular structured hydrogels

AU - Wei, Hongliang

AU - Yu, Huaiqing

AU - Zhang, Ai Ying

AU - Sun, Ling Gang

AU - Hou, Dandan

AU - Feng, Zeng Guo

PY - 2005/10/18

Y1 - 2005/10/18

N2 - New kinds of thermosensitive and supramolecular structured hydrogels were synthesized via copolymerization of N-isopropylacrylamide (NIPA) with photocurable and biodegradable polypseudorotaxanes as cross-linkers under UV irradiation. The polypseudorotaxanes were prepared by supramolecular self-assemblies of α-cyclodextrins threaded onto amphiphilic LA-PEG-LA copolymers end-capped with methacryloyl groups. The structure of the hydrogels was characterized in detail with FTIR, 1H NMR, XRD, DSC, and TGA techniques. The analytical results have demonstrated that the channel-type crystalline structure of inclusion complexes (ICs) remains in as-obtained hydrogels. Their swelling behavior was measured gravimetrically in the temperature range from 22 to 67 °C. It was observed that the crosslinked hydrogel made of only the macromer guest shows also thermosensitive. However, this stimuli-responsive property disappears when α-CDs are threaded onto the polymeric backbone and reappears when PNIPA blocks are introduced. The theromsensitivity of these hydrogels could be modulated by changing the PNIPA content as well as the α-CD to macromer ratio.

AB - New kinds of thermosensitive and supramolecular structured hydrogels were synthesized via copolymerization of N-isopropylacrylamide (NIPA) with photocurable and biodegradable polypseudorotaxanes as cross-linkers under UV irradiation. The polypseudorotaxanes were prepared by supramolecular self-assemblies of α-cyclodextrins threaded onto amphiphilic LA-PEG-LA copolymers end-capped with methacryloyl groups. The structure of the hydrogels was characterized in detail with FTIR, 1H NMR, XRD, DSC, and TGA techniques. The analytical results have demonstrated that the channel-type crystalline structure of inclusion complexes (ICs) remains in as-obtained hydrogels. Their swelling behavior was measured gravimetrically in the temperature range from 22 to 67 °C. It was observed that the crosslinked hydrogel made of only the macromer guest shows also thermosensitive. However, this stimuli-responsive property disappears when α-CDs are threaded onto the polymeric backbone and reappears when PNIPA blocks are introduced. The theromsensitivity of these hydrogels could be modulated by changing the PNIPA content as well as the α-CD to macromer ratio.

UR - http://www.scopus.com/inward/record.url?scp=27344458873&partnerID=8YFLogxK

U2 - 10.1021/ma050887p

DO - 10.1021/ma050887p

M3 - Article

AN - SCOPUS:27344458873

SN - 0024-9297

VL - 38

SP - 8833

EP - 8839

JO - Macromolecules

JF - Macromolecules

IS - 21

ER -

Synthesis and characterization of thermosensitive and supramolecular structured hydrogels

Abstract

Access to Document

Other files and links

Fingerprint

Cite this