Synthesis and characterization of injectable supramolecular structured hydrogels prepared by free radical polymerization of PLA-b-PEG-b-PLA macromers and α-cyclodextrins

Kai Qiang Zhu; Hong Liang Wei; Ji Yu He; Li Jun Qian; Dan Dan Hou; Ai Ying Zhang; Zeng Guo Feng

Synthesis and characterization of injectable supramolecular structured hydrogels prepared by free radical polymerization of PLA-b-PEG-b-PLA macromers and α-cyclodextrins

Kai Qiang Zhu^*, Hong Liang Wei, Ji Yu He, Li Jun Qian, Dan Dan Hou, Ai Ying Zhang, Zeng Guo Feng

^*Corresponding author for this work

School of Material Science and Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Poly(L-lactide)-poly(ethylene glycol)-poly(L-lactide) triblock copolymer (PLA-PEG-PLA) was synthesized by the ring-opening polymerization of L-lactide with poly(ethylene glycol) (PEG6000) as the initiator and Sn(Oct)₂ as the catalyst in toluene. This copolymer was further reacted with methacrylic anhydride to give a soluble macromer terminated with methacryloyl groups. Two kinds of supramolecular structured hydro-gels were obtained through mixing the macromer with α-cyclodextrins and then initiating by using ammonium persulphate with ascorbic acid or ferrous sulfate. The macromer and hydrogels were characterized by ¹H NMR, FTIR, TGA and XRD etc.. Based on rheological test, the two kinds of the resultant hydrogels are injectable with appropriate pot-life.

Original language	English
Pages (from-to)	2160-2164
Number of pages	5
Journal	Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities
Volume	26
Issue number	11
Publication status	Published - Nov 2005

Keywords

Injectable property
Macromers
Redox initiator
Supramolecular structured hydrogel
α-Cyclodextrins

Cite this

Zhu, K. Q., Wei, H. L., He, J. Y., Qian, L. J., Hou, D. D., Zhang, A. Y., & Feng, Z. G. (2005). Synthesis and characterization of injectable supramolecular structured hydrogels prepared by free radical polymerization of PLA-b-PEG-b-PLA macromers and α-cyclodextrins. Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities, 26(11), 2160-2164.

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title = "Synthesis and characterization of injectable supramolecular structured hydrogels prepared by free radical polymerization of PLA-b-PEG-b-PLA macromers and α-cyclodextrins",

abstract = "Poly(L-lactide)-poly(ethylene glycol)-poly(L-lactide) triblock copolymer (PLA-PEG-PLA) was synthesized by the ring-opening polymerization of L-lactide with poly(ethylene glycol) (PEG6000) as the initiator and Sn(Oct)2 as the catalyst in toluene. This copolymer was further reacted with methacrylic anhydride to give a soluble macromer terminated with methacryloyl groups. Two kinds of supramolecular structured hydro-gels were obtained through mixing the macromer with α-cyclodextrins and then initiating by using ammonium persulphate with ascorbic acid or ferrous sulfate. The macromer and hydrogels were characterized by 1H NMR, FTIR, TGA and XRD etc.. Based on rheological test, the two kinds of the resultant hydrogels are injectable with appropriate pot-life.",

keywords = "Injectable property, Macromers, Redox initiator, Supramolecular structured hydrogel, α-Cyclodextrins",

author = "Zhu, {Kai Qiang} and Wei, {Hong Liang} and He, {Ji Yu} and Qian, {Li Jun} and Hou, {Dan Dan} and Zhang, {Ai Ying} and Feng, {Zeng Guo}",

year = "2005",

month = nov,

language = "English",

volume = "26",

pages = "2160--2164",

journal = "Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities",

issn = "0251-0790",

publisher = "Higher Education Press Limited Company",

number = "11",

}

Synthesis and characterization of injectable supramolecular structured hydrogels prepared by free radical polymerization of PLA-b-PEG-b-PLA macromers and α-cyclodextrins. / Zhu, Kai Qiang; Wei, Hong Liang; He, Ji Yu et al.
In: Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities, Vol. 26, No. 11, 11.2005, p. 2160-2164.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis and characterization of injectable supramolecular structured hydrogels prepared by free radical polymerization of PLA-b-PEG-b-PLA macromers and α-cyclodextrins

AU - Zhu, Kai Qiang

AU - Wei, Hong Liang

AU - He, Ji Yu

AU - Qian, Li Jun

AU - Hou, Dan Dan

AU - Zhang, Ai Ying

AU - Feng, Zeng Guo

PY - 2005/11

Y1 - 2005/11

N2 - Poly(L-lactide)-poly(ethylene glycol)-poly(L-lactide) triblock copolymer (PLA-PEG-PLA) was synthesized by the ring-opening polymerization of L-lactide with poly(ethylene glycol) (PEG6000) as the initiator and Sn(Oct)2 as the catalyst in toluene. This copolymer was further reacted with methacrylic anhydride to give a soluble macromer terminated with methacryloyl groups. Two kinds of supramolecular structured hydro-gels were obtained through mixing the macromer with α-cyclodextrins and then initiating by using ammonium persulphate with ascorbic acid or ferrous sulfate. The macromer and hydrogels were characterized by 1H NMR, FTIR, TGA and XRD etc.. Based on rheological test, the two kinds of the resultant hydrogels are injectable with appropriate pot-life.

AB - Poly(L-lactide)-poly(ethylene glycol)-poly(L-lactide) triblock copolymer (PLA-PEG-PLA) was synthesized by the ring-opening polymerization of L-lactide with poly(ethylene glycol) (PEG6000) as the initiator and Sn(Oct)2 as the catalyst in toluene. This copolymer was further reacted with methacrylic anhydride to give a soluble macromer terminated with methacryloyl groups. Two kinds of supramolecular structured hydro-gels were obtained through mixing the macromer with α-cyclodextrins and then initiating by using ammonium persulphate with ascorbic acid or ferrous sulfate. The macromer and hydrogels were characterized by 1H NMR, FTIR, TGA and XRD etc.. Based on rheological test, the two kinds of the resultant hydrogels are injectable with appropriate pot-life.

KW - Injectable property

KW - Macromers

KW - Redox initiator

KW - Supramolecular structured hydrogel

KW - α-Cyclodextrins

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M3 - Article

AN - SCOPUS:28744441493

SN - 0251-0790

VL - 26

SP - 2160

EP - 2164

JO - Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities

JF - Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities

IS - 11

ER -

Synthesis and characterization of injectable supramolecular structured hydrogels prepared by free radical polymerization of PLA-b-PEG-b-PLA macromers and α-cyclodextrins

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