Synthesis and activities of derivatives of magnolol and honokiol

Xiaodi Li; Xinglong Guo; Rongji Dai; Fang Lyu; Lin Cong; Yulin Deng

doi:10.11665/j.issn.1000-5048.20170505

Synthesis and activities of derivatives of magnolol and honokiol

Xiaodi Li, Xinglong Guo, Rongji Dai, Fang Lyu, Lin Cong, Yulin Deng

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Based on the chemical structures of magnolol and honokiol, a series of small molecular derivatives were designed for the treatment of Alzheimer's disease. Through the Discovery Studio, five compounds (6a-6e) exhibited the inhibitory activity against Aβ and Tau proteins in all of the designed compounds. Then the five compounds are chemically synthesized and their biological activities were tested by thioflavin T. The result showed that compound 6a had inhibitory effect on the aggregation of two kinds of target proteins at the concentration of 100 μmol/L, which deserves further research.

Original language	English
Pages (from-to)	536-542
Number of pages	7
Journal	Journal of China Pharmaceutical University
Volume	48
Issue number	5
DOIs	https://doi.org/10.11665/j.issn.1000-5048.20170505
Publication status	Published - Oct 2017

Keywords

Activity
Alzheimer's disease
Aβ protein inhibitor
Derivative
Honokiol
Magnolol
Synthesis

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10.11665/j.issn.1000-5048.20170505

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title = "Synthesis and activities of derivatives of magnolol and honokiol",

abstract = "Based on the chemical structures of magnolol and honokiol, a series of small molecular derivatives were designed for the treatment of Alzheimer's disease. Through the Discovery Studio, five compounds (6a-6e) exhibited the inhibitory activity against Aβ and Tau proteins in all of the designed compounds. Then the five compounds are chemically synthesized and their biological activities were tested by thioflavin T. The result showed that compound 6a had inhibitory effect on the aggregation of two kinds of target proteins at the concentration of 100 μmol/L, which deserves further research.",

keywords = "Activity, Alzheimer's disease, Aβ protein inhibitor, Derivative, Honokiol, Magnolol, Synthesis",

author = "Xiaodi Li and Xinglong Guo and Rongji Dai and Fang Lyu and Lin Cong and Yulin Deng",

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T1 - Synthesis and activities of derivatives of magnolol and honokiol

AU - Li, Xiaodi

AU - Guo, Xinglong

AU - Dai, Rongji

AU - Lyu, Fang

AU - Cong, Lin

AU - Deng, Yulin

PY - 2017/10

Y1 - 2017/10

N2 - Based on the chemical structures of magnolol and honokiol, a series of small molecular derivatives were designed for the treatment of Alzheimer's disease. Through the Discovery Studio, five compounds (6a-6e) exhibited the inhibitory activity against Aβ and Tau proteins in all of the designed compounds. Then the five compounds are chemically synthesized and their biological activities were tested by thioflavin T. The result showed that compound 6a had inhibitory effect on the aggregation of two kinds of target proteins at the concentration of 100 μmol/L, which deserves further research.

AB - Based on the chemical structures of magnolol and honokiol, a series of small molecular derivatives were designed for the treatment of Alzheimer's disease. Through the Discovery Studio, five compounds (6a-6e) exhibited the inhibitory activity against Aβ and Tau proteins in all of the designed compounds. Then the five compounds are chemically synthesized and their biological activities were tested by thioflavin T. The result showed that compound 6a had inhibitory effect on the aggregation of two kinds of target proteins at the concentration of 100 μmol/L, which deserves further research.

KW - Activity

KW - Alzheimer's disease

KW - Aβ protein inhibitor

KW - Derivative

KW - Honokiol

KW - Magnolol

KW - Synthesis

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SP - 536

EP - 542

JO - Journal of China Pharmaceutical University

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ER -

Synthesis and activities of derivatives of magnolol and honokiol

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Keywords

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