Surface-initiated atom-transfer radical polymerization (SI-ATRP) of bactericidal polymer brushes on poly(lactic acid) surfaces

Pranav P. Kalelkar; Zhishuai Geng; Bronson Cox; M. G. Finn; David M. Collard

doi:10.1016/j.colsurfb.2021.112242

Surface-initiated atom-transfer radical polymerization (SI-ATRP) of bactericidal polymer brushes on poly(lactic acid) surfaces

Pranav P. Kalelkar, Zhishuai Geng, Bronson Cox, M. G. Finn, David M. Collard^*

^*Corresponding author for this work

Georgia Institute of Technology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We have modified the surface of poly(lactic acid) (PLA) by bromination in the presence of N-bromosuccinimide (NBS) under UV irradiation. This new approach to impart functionality to the surface does not effect the bulk of the material. Brominated PLA surfaces served as initiators for atom-transfer radical polymerization (SI-ATRP) of 2-(methacryloyloxy)ethyl]trimethylammonium chloride, a quaternary ammonium methacrylate (QMA). Grafting of poly(QMA) brushes rendered PLA films hydrophilic and these films displayed a three-order of magnitude increase in antimicrobial efficacy against Gram-negative bacteria such as Escherichia coli as compared to unmodified PLA. The two-step strategy described here to modify PLA surface represents a useful route to modified PLA materials for biomedical and antimicrobial packaging applications.

Original language	English
Article number	112242
Journal	Colloids and Surfaces B: Biointerfaces
Volume	211
DOIs	https://doi.org/10.1016/j.colsurfb.2021.112242
Publication status	Published - Mar 2022
Externally published	Yes

Keywords

Antimicrobial materials
Atom transfer radical polymerization
Poly(lactic acid)

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10.1016/j.colsurfb.2021.112242

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title = "Surface-initiated atom-transfer radical polymerization (SI-ATRP) of bactericidal polymer brushes on poly(lactic acid) surfaces",

abstract = "We have modified the surface of poly(lactic acid) (PLA) by bromination in the presence of N-bromosuccinimide (NBS) under UV irradiation. This new approach to impart functionality to the surface does not effect the bulk of the material. Brominated PLA surfaces served as initiators for atom-transfer radical polymerization (SI-ATRP) of 2-(methacryloyloxy)ethyl]trimethylammonium chloride, a quaternary ammonium methacrylate (QMA). Grafting of poly(QMA) brushes rendered PLA films hydrophilic and these films displayed a three-order of magnitude increase in antimicrobial efficacy against Gram-negative bacteria such as Escherichia coli as compared to unmodified PLA. The two-step strategy described here to modify PLA surface represents a useful route to modified PLA materials for biomedical and antimicrobial packaging applications.",

keywords = "Antimicrobial materials, Atom transfer radical polymerization, Poly(lactic acid)",

author = "Kalelkar, {Pranav P.} and Zhishuai Geng and Bronson Cox and Finn, {M. G.} and Collard, {David M.}",

note = "Publisher Copyright: {\textcopyright} 2021",

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month = mar,

doi = "10.1016/j.colsurfb.2021.112242",

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AU - Kalelkar, Pranav P.

AU - Geng, Zhishuai

AU - Cox, Bronson

AU - Finn, M. G.

AU - Collard, David M.

PY - 2022/3

Y1 - 2022/3

N2 - We have modified the surface of poly(lactic acid) (PLA) by bromination in the presence of N-bromosuccinimide (NBS) under UV irradiation. This new approach to impart functionality to the surface does not effect the bulk of the material. Brominated PLA surfaces served as initiators for atom-transfer radical polymerization (SI-ATRP) of 2-(methacryloyloxy)ethyl]trimethylammonium chloride, a quaternary ammonium methacrylate (QMA). Grafting of poly(QMA) brushes rendered PLA films hydrophilic and these films displayed a three-order of magnitude increase in antimicrobial efficacy against Gram-negative bacteria such as Escherichia coli as compared to unmodified PLA. The two-step strategy described here to modify PLA surface represents a useful route to modified PLA materials for biomedical and antimicrobial packaging applications.

AB - We have modified the surface of poly(lactic acid) (PLA) by bromination in the presence of N-bromosuccinimide (NBS) under UV irradiation. This new approach to impart functionality to the surface does not effect the bulk of the material. Brominated PLA surfaces served as initiators for atom-transfer radical polymerization (SI-ATRP) of 2-(methacryloyloxy)ethyl]trimethylammonium chloride, a quaternary ammonium methacrylate (QMA). Grafting of poly(QMA) brushes rendered PLA films hydrophilic and these films displayed a three-order of magnitude increase in antimicrobial efficacy against Gram-negative bacteria such as Escherichia coli as compared to unmodified PLA. The two-step strategy described here to modify PLA surface represents a useful route to modified PLA materials for biomedical and antimicrobial packaging applications.

KW - Antimicrobial materials

KW - Atom transfer radical polymerization

KW - Poly(lactic acid)

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U2 - 10.1016/j.colsurfb.2021.112242

DO - 10.1016/j.colsurfb.2021.112242

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SN - 0927-7765

VL - 211

JO - Colloids and Surfaces B: Biointerfaces

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ER -

Surface-initiated atom-transfer radical polymerization (SI-ATRP) of bactericidal polymer brushes on poly(lactic acid) surfaces

Abstract

Keywords

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