Superparamagnetic Iron Oxide Nanoparticles and Static Magnetic Field Regulate Neural Stem Cell Proliferation

Dan Li; Yangnan Hu; Hao Wei; Wei Chen; Yun Liu; Xiaoqian Yan; Lingna Guo; Menghui Liao; Bo Chen; Renjie Chai; Mingliang Tang

doi:10.3389/fncel.2021.815280

Superparamagnetic Iron Oxide Nanoparticles and Static Magnetic Field Regulate Neural Stem Cell Proliferation

Dan Li, Yangnan Hu, Hao Wei, Wei Chen, Yun Liu, Xiaoqian Yan, Lingna Guo, Menghui Liao, Bo Chen, Renjie Chai^*, Mingliang Tang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Neural stem cells (NSCs) transplantation is a promising approach for the treatment of various neurodegenerative diseases. Superparamagnetic iron oxide nanoparticles (SPIOs) are reported to modulate stem cell behaviors and are used for medical imaging. However, the detailed effects of SPIOs under the presence of static magnetic field (SMF) on NSCs are not well elucidated. In this study, it was found that SPIOs could enter the cells within 24 h, while they were mainly distributed in the lysosomes. SPIO exhibited good adhesion and excellent biocompatibility at concentrations below 500 μg/ml. In addition, SPIOs were able to promote NSC proliferation in the absence of SMF. In contrast, the high intensity of SMF (145 ± 10 mT) inhibited the expansion ability of NSCs. Our results demonstrate that SPIOs with SMF could promote NSC proliferation, which could have profound significance for tissue engineering and regenerative medicine for SPIO applications.

Original language	English
Article number	815280
Journal	Frontiers in Cellular Neuroscience
Volume	15
DOIs	https://doi.org/10.3389/fncel.2021.815280
Publication status	Published - 4 Feb 2022
Externally published	Yes

Keywords

SMF
SPIO
neural stem cells
proliferation
regulation

Access to Document

10.3389/fncel.2021.815280

Cite this

@article{8caa6f47424b414f86e00442d4f130c3,

title = "Superparamagnetic Iron Oxide Nanoparticles and Static Magnetic Field Regulate Neural Stem Cell Proliferation",

abstract = "Neural stem cells (NSCs) transplantation is a promising approach for the treatment of various neurodegenerative diseases. Superparamagnetic iron oxide nanoparticles (SPIOs) are reported to modulate stem cell behaviors and are used for medical imaging. However, the detailed effects of SPIOs under the presence of static magnetic field (SMF) on NSCs are not well elucidated. In this study, it was found that SPIOs could enter the cells within 24 h, while they were mainly distributed in the lysosomes. SPIO exhibited good adhesion and excellent biocompatibility at concentrations below 500 μg/ml. In addition, SPIOs were able to promote NSC proliferation in the absence of SMF. In contrast, the high intensity of SMF (145 ± 10 mT) inhibited the expansion ability of NSCs. Our results demonstrate that SPIOs with SMF could promote NSC proliferation, which could have profound significance for tissue engineering and regenerative medicine for SPIO applications.",

keywords = "SMF, SPIO, neural stem cells, proliferation, regulation",

author = "Dan Li and Yangnan Hu and Hao Wei and Wei Chen and Yun Liu and Xiaoqian Yan and Lingna Guo and Menghui Liao and Bo Chen and Renjie Chai and Mingliang Tang",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Li, Hu, Wei, Chen, Liu, Yan, Guo, Liao, Chen, Chai and Tang.",

year = "2022",

month = feb,

day = "4",

doi = "10.3389/fncel.2021.815280",

language = "English",

volume = "15",

journal = "Frontiers in Cellular Neuroscience",

issn = "1662-5102",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - Superparamagnetic Iron Oxide Nanoparticles and Static Magnetic Field Regulate Neural Stem Cell Proliferation

AU - Li, Dan

AU - Hu, Yangnan

AU - Wei, Hao

AU - Chen, Wei

AU - Liu, Yun

AU - Yan, Xiaoqian

AU - Guo, Lingna

AU - Liao, Menghui

AU - Chen, Bo

AU - Chai, Renjie

AU - Tang, Mingliang

PY - 2022/2/4

Y1 - 2022/2/4

N2 - Neural stem cells (NSCs) transplantation is a promising approach for the treatment of various neurodegenerative diseases. Superparamagnetic iron oxide nanoparticles (SPIOs) are reported to modulate stem cell behaviors and are used for medical imaging. However, the detailed effects of SPIOs under the presence of static magnetic field (SMF) on NSCs are not well elucidated. In this study, it was found that SPIOs could enter the cells within 24 h, while they were mainly distributed in the lysosomes. SPIO exhibited good adhesion and excellent biocompatibility at concentrations below 500 μg/ml. In addition, SPIOs were able to promote NSC proliferation in the absence of SMF. In contrast, the high intensity of SMF (145 ± 10 mT) inhibited the expansion ability of NSCs. Our results demonstrate that SPIOs with SMF could promote NSC proliferation, which could have profound significance for tissue engineering and regenerative medicine for SPIO applications.

AB - Neural stem cells (NSCs) transplantation is a promising approach for the treatment of various neurodegenerative diseases. Superparamagnetic iron oxide nanoparticles (SPIOs) are reported to modulate stem cell behaviors and are used for medical imaging. However, the detailed effects of SPIOs under the presence of static magnetic field (SMF) on NSCs are not well elucidated. In this study, it was found that SPIOs could enter the cells within 24 h, while they were mainly distributed in the lysosomes. SPIO exhibited good adhesion and excellent biocompatibility at concentrations below 500 μg/ml. In addition, SPIOs were able to promote NSC proliferation in the absence of SMF. In contrast, the high intensity of SMF (145 ± 10 mT) inhibited the expansion ability of NSCs. Our results demonstrate that SPIOs with SMF could promote NSC proliferation, which could have profound significance for tissue engineering and regenerative medicine for SPIO applications.

KW - SMF

KW - SPIO

KW - neural stem cells

KW - proliferation

KW - regulation

UR - http://www.scopus.com/inward/record.url?scp=85124909897&partnerID=8YFLogxK

U2 - 10.3389/fncel.2021.815280

DO - 10.3389/fncel.2021.815280

M3 - Article

AN - SCOPUS:85124909897

SN - 1662-5102

VL - 15

JO - Frontiers in Cellular Neuroscience

JF - Frontiers in Cellular Neuroscience

M1 - 815280

ER -

Superparamagnetic Iron Oxide Nanoparticles and Static Magnetic Field Regulate Neural Stem Cell Proliferation

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this