Substrate-Free Dissolvable Microneedles with Barbed Structure Prepared by Modified Dual-Moulding Processes

Yingjie Ren; Junshi Li; Dong Huang; Lu Cao; Pengfei Wu; Yuanyu Huang; Zhihong Li

doi:10.1109/MEMS51670.2022.9699679

Substrate-Free Dissolvable Microneedles with Barbed Structure Prepared by Modified Dual-Moulding Processes

Yingjie Ren, Junshi Li, Dong Huang, Lu Cao, Pengfei Wu, Yuanyu Huang, Zhihong Li^*

^*Corresponding author for this work

Advanced Research Institute of Multidisciplinary Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

As an emerging approach in the field of drug delivery, dissolvable microneedles have been extensively developed and applied. Most of the tips are with the conical or pyramid-shap, which allows low penetration force, but the tips are easy to slip out of the skin. Moreover, the medicine in the substrate cannot be used, resulting in waste of medicine. Based on the above problems, this paper reports a new type of substrate-free dissolvable microneedles with the barbed structure, which are prepared by modified dual-moulding processes and have the potential for mass production. Compared with the traditional conical microneedle, the barbed microneedle has stronger adhesion to the skin, and takes shorter pressing time to produce more drug dissolution amount and deeper penetration depth to ensure effective transdermal delivery.

Original language	English
Title of host publication	35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	404-407
Number of pages	4
ISBN (Electronic)	9781665409117
DOIs	https://doi.org/10.1109/MEMS51670.2022.9699679
Publication status	Published - 2022
Event	35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022 - Tokyo, Japan Duration: 9 Jan 2022 → 13 Jan 2022

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2022-January
ISSN (Print)	1084-6999

Conference

Conference	35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022
Country/Territory	Japan
City	Tokyo
Period	9/01/22 → 13/01/22

Keywords

Barbed structure
Dissolvable microneedles
Drug delivery
Transdermal

Access to Document

10.1109/MEMS51670.2022.9699679

Cite this

Ren, Y., Li, J., Huang, D., Cao, L., Wu, P., Huang, Y., & Li, Z. (2022). Substrate-Free Dissolvable Microneedles with Barbed Structure Prepared by Modified Dual-Moulding Processes. In 35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022 (pp. 404-407). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2022-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMS51670.2022.9699679

Ren, Yingjie ; Li, Junshi ; Huang, Dong et al. / Substrate-Free Dissolvable Microneedles with Barbed Structure Prepared by Modified Dual-Moulding Processes. 35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022. Institute of Electrical and Electronics Engineers Inc., 2022. pp. 404-407 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

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title = "Substrate-Free Dissolvable Microneedles with Barbed Structure Prepared by Modified Dual-Moulding Processes",

abstract = "As an emerging approach in the field of drug delivery, dissolvable microneedles have been extensively developed and applied. Most of the tips are with the conical or pyramid-shap, which allows low penetration force, but the tips are easy to slip out of the skin. Moreover, the medicine in the substrate cannot be used, resulting in waste of medicine. Based on the above problems, this paper reports a new type of substrate-free dissolvable microneedles with the barbed structure, which are prepared by modified dual-moulding processes and have the potential for mass production. Compared with the traditional conical microneedle, the barbed microneedle has stronger adhesion to the skin, and takes shorter pressing time to produce more drug dissolution amount and deeper penetration depth to ensure effective transdermal delivery.",

keywords = "Barbed structure, Dissolvable microneedles, Drug delivery, Transdermal",

author = "Yingjie Ren and Junshi Li and Dong Huang and Lu Cao and Pengfei Wu and Yuanyu Huang and Zhihong Li",

note = "Publisher Copyright: {\textcopyright} 2022 IEEE.; 35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022 ; Conference date: 09-01-2022 Through 13-01-2022",

year = "2022",

doi = "10.1109/MEMS51670.2022.9699679",

language = "English",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

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Ren, Y, Li, J, Huang, D, Cao, L, Wu, P, Huang, Y & Li, Z 2022, Substrate-Free Dissolvable Microneedles with Barbed Structure Prepared by Modified Dual-Moulding Processes. in 35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2022-January, Institute of Electrical and Electronics Engineers Inc., pp. 404-407, 35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022, Tokyo, Japan, 9/01/22. https://doi.org/10.1109/MEMS51670.2022.9699679

Substrate-Free Dissolvable Microneedles with Barbed Structure Prepared by Modified Dual-Moulding Processes. / Ren, Yingjie; Li, Junshi; Huang, Dong et al.
35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022. Institute of Electrical and Electronics Engineers Inc., 2022. p. 404-407 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2022-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Ren, Yingjie

AU - Li, Junshi

AU - Huang, Dong

AU - Cao, Lu

AU - Wu, Pengfei

AU - Huang, Yuanyu

AU - Li, Zhihong

PY - 2022

Y1 - 2022

N2 - As an emerging approach in the field of drug delivery, dissolvable microneedles have been extensively developed and applied. Most of the tips are with the conical or pyramid-shap, which allows low penetration force, but the tips are easy to slip out of the skin. Moreover, the medicine in the substrate cannot be used, resulting in waste of medicine. Based on the above problems, this paper reports a new type of substrate-free dissolvable microneedles with the barbed structure, which are prepared by modified dual-moulding processes and have the potential for mass production. Compared with the traditional conical microneedle, the barbed microneedle has stronger adhesion to the skin, and takes shorter pressing time to produce more drug dissolution amount and deeper penetration depth to ensure effective transdermal delivery.

AB - As an emerging approach in the field of drug delivery, dissolvable microneedles have been extensively developed and applied. Most of the tips are with the conical or pyramid-shap, which allows low penetration force, but the tips are easy to slip out of the skin. Moreover, the medicine in the substrate cannot be used, resulting in waste of medicine. Based on the above problems, this paper reports a new type of substrate-free dissolvable microneedles with the barbed structure, which are prepared by modified dual-moulding processes and have the potential for mass production. Compared with the traditional conical microneedle, the barbed microneedle has stronger adhesion to the skin, and takes shorter pressing time to produce more drug dissolution amount and deeper penetration depth to ensure effective transdermal delivery.

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Ren Y, Li J, Huang D, Cao L, Wu P, Huang Y et al. Substrate-Free Dissolvable Microneedles with Barbed Structure Prepared by Modified Dual-Moulding Processes. In 35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022. Institute of Electrical and Electronics Engineers Inc. 2022. p. 404-407. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMS51670.2022.9699679

Substrate-Free Dissolvable Microneedles with Barbed Structure Prepared by Modified Dual-Moulding Processes

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Keywords

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