TY - JOUR
T1 - Study on Pharmacokinetics and Excretion of Loureirin B in Rats Under Simulated Weightlessness Condition
AU - Chen, Bo
AU - Zhang, Yu Shi
AU - Su, Jing
AU - Wang, Rui
AU - Deng, Yu Lin
AU - Li, Yu Juan
N1 - Publisher Copyright:
© 2017, Editorial Department of Transaction of Beijing Institute of Technology. All right reserved.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - To study pharmacokinetics and excretion difference of loureirin B (LB) in rats after single oral administration between simulated weightlessness and gravitation condition, a series of test was executed. Rats were tail-suspended for 21 days to simulate weightlessness effect. After a single oral administration of 25 mg/kg LB, venous blood and excretion samples were collected at different time points. Concentration of LB in samples was determined by HPLC-MS method. Pharmacokinetic parameters and excretion amount were calculated. Results show that, compared with normal gravity rats, the area under cuve (AUC0-t), maximum concentration (Cmax), time to peak concentration (tmax), volume of distribution (Vd), elimination rate constant (Ke), and biological half-life (T1/2) of simulated weightless rats ware significantly changed. Meanwhile, the excretion of LB in urine, feces, and bile are also up-regulated in simulated weightlessness group, while no obvious differences are observed.
AB - To study pharmacokinetics and excretion difference of loureirin B (LB) in rats after single oral administration between simulated weightlessness and gravitation condition, a series of test was executed. Rats were tail-suspended for 21 days to simulate weightlessness effect. After a single oral administration of 25 mg/kg LB, venous blood and excretion samples were collected at different time points. Concentration of LB in samples was determined by HPLC-MS method. Pharmacokinetic parameters and excretion amount were calculated. Results show that, compared with normal gravity rats, the area under cuve (AUC0-t), maximum concentration (Cmax), time to peak concentration (tmax), volume of distribution (Vd), elimination rate constant (Ke), and biological half-life (T1/2) of simulated weightless rats ware significantly changed. Meanwhile, the excretion of LB in urine, feces, and bile are also up-regulated in simulated weightlessness group, while no obvious differences are observed.
KW - Excretion
KW - Loureirin B
KW - Pharmacokinetics
KW - Simulated weightlessness
UR - http://www.scopus.com/inward/record.url?scp=85031702192&partnerID=8YFLogxK
U2 - 10.15918/j.tbit1001-0645.2017.08.019
DO - 10.15918/j.tbit1001-0645.2017.08.019
M3 - Article
AN - SCOPUS:85031702192
SN - 1001-0645
VL - 37
SP - 875
EP - 880
JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
IS - 8
ER -