Specific light-up bioprobe with aggregation-induced emission and activatable photoactivity for the targeted and image-guided photodynamic ablation of cancer cells

Youyong Yuan, Chong Jing Zhang, Meng Gao, Ruoyu Zhang, Ben Zhong Tang, Bin Liu

Research output: Contribution to journalArticlepeer-review

459 Citations (Scopus)

Abstract

Activatable photosensitizers (PSs) have been widely used for the simultaneous fluorescence imaging and photodynamic ablation of cancer cells. However, the ready aggregation of traditional PSs in aqueous media can lead to fluorescence quenching as well as reduced phototoxicity even in the activated form. We have developed a series of PSs that show aggregation-enhanced emission and phototoxicity and thus the exact opposite behavior to that of previously reported PSs. We further developed a dual-targeted enzyme-activatable bioprobe based on the optimized photosensitizer and describe simultaneous light-up fluorescence imaging and activated photodynamic therapy for specific cancer cells. The design of smart probes should thus open new opportunities for targeted and image-guided photodynamic therapy.

Original languageEnglish
Pages (from-to)1780-1786
Number of pages7
JournalAngewandte Chemie - International Edition
Volume54
Issue number6
DOIs
Publication statusPublished - 9 Feb 2015
Externally publishedYes

Keywords

  • Aggregation-induced emission (aie)
  • Cancer
  • Fluorescence imaging
  • Image-guided therapy
  • Photodynamic therapy

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