Six new C-21 steroidal glycosides from Dregea sinensis Hemsl

Xiu Jie Liu; Yu Shi; Shao Hua Jia; Yu Lin Deng; Fang Lv; Rong Ji Dai

doi:10.1080/10286020.2017.1281912

Six new C-21 steroidal glycosides from Dregea sinensis Hemsl

Xiu Jie Liu, Yu Shi, Shao Hua Jia, Yu Lin Deng, Fang Lv^*, Rong Ji Dai

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Six new C-21 steroidal glycosides (1–6) were separated from the root of Dregea sinensis Hemsl. and their structures were elucidated using extensive nuclear magnetic resonance, mass spectrometry, and infrared spectral analyses. Isolated compounds were evaluated for antitumor activity, which showed that compound 3 had moderate activity in Jurkat cells (IC₅₀ 19.54 ± 0.91 μM), and compounds 1–4 had significant effects against IL-2R and TNFR2 (IC₅₀ 1.518 ± 0.06 μM to 5.9 ± 0.07 μM).

Original language	English
Pages (from-to)	745-753
Number of pages	9
Journal	Journal of Asian Natural Products Research
Volume	19
Issue number	8
DOIs	https://doi.org/10.1080/10286020.2017.1281912
Publication status	Published - 2017

Keywords

C-21 steroidal glycosides
Dregea sinensis
anticancer activity
structure–activity relationship

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10.1080/10286020.2017.1281912

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title = "Six new C-21 steroidal glycosides from Dregea sinensis Hemsl",

abstract = "Six new C-21 steroidal glycosides (1–6) were separated from the root of Dregea sinensis Hemsl. and their structures were elucidated using extensive nuclear magnetic resonance, mass spectrometry, and infrared spectral analyses. Isolated compounds were evaluated for antitumor activity, which showed that compound 3 had moderate activity in Jurkat cells (IC50 19.54 ± 0.91 μM), and compounds 1–4 had significant effects against IL-2R and TNFR2 (IC50 1.518 ± 0.06 μM to 5.9 ± 0.07 μM).",

keywords = "C-21 steroidal glycosides, Dregea sinensis, anticancer activity, structure–activity relationship",

author = "Liu, {Xiu Jie} and Yu Shi and Jia, {Shao Hua} and Deng, {Yu Lin} and Fang Lv and Dai, {Rong Ji}",

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AU - Shi, Yu

AU - Jia, Shao Hua

AU - Deng, Yu Lin

AU - Lv, Fang

AU - Dai, Rong Ji

PY - 2017

Y1 - 2017

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AB - Six new C-21 steroidal glycosides (1–6) were separated from the root of Dregea sinensis Hemsl. and their structures were elucidated using extensive nuclear magnetic resonance, mass spectrometry, and infrared spectral analyses. Isolated compounds were evaluated for antitumor activity, which showed that compound 3 had moderate activity in Jurkat cells (IC50 19.54 ± 0.91 μM), and compounds 1–4 had significant effects against IL-2R and TNFR2 (IC50 1.518 ± 0.06 μM to 5.9 ± 0.07 μM).

KW - C-21 steroidal glycosides

KW - Dregea sinensis

KW - anticancer activity

KW - structure–activity relationship

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JO - Journal of Asian Natural Products Research

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ER -

Six new C-21 steroidal glycosides from Dregea sinensis Hemsl

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Keywords

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