Separation and identification of the main impurity in erythromycin oxime

Dong Ye; Zhi Hua Deng; Jian Hua Liang; Xiao Hong Jin; Jing Rui Bai; Guo Wei Yao

Separation and identification of the main impurity in erythromycin oxime

Dong Ye^*, Zhi Hua Deng, Jian Hua Liang, Xiao Hong Jin, Jing Rui Bai, Guo Wei Yao

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The oximation of erythromycin is studied. The main impurity involved in the synthesis of erythromycin oxime was separated and purified, which was identified as the very compound formed in the acidic hydrolysis of erythromycin A, i. e erythromycin A8,9-dehydro-6,9-hemiketal. This result shows that the oximation of erythromycin is always accompanied with its acidic degradation, and therefore that it is important to control the amount of acid used as catalyst.

Original language	English
Pages (from-to)	244-246+250
Journal	He Jishu/Nuclear Techniques
Volume	22
Issue number	2
Publication status	Published - 1999

Keywords

Erythromycin a 6,9-hemiketal
Erythromycin a 8,9-dehydro-6,9-hemiketal
Erythromycin oxime

Cite this

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title = "Separation and identification of the main impurity in erythromycin oxime",

abstract = "The oximation of erythromycin is studied. The main impurity involved in the synthesis of erythromycin oxime was separated and purified, which was identified as the very compound formed in the acidic hydrolysis of erythromycin A, i. e erythromycin A8,9-dehydro-6,9-hemiketal. This result shows that the oximation of erythromycin is always accompanied with its acidic degradation, and therefore that it is important to control the amount of acid used as catalyst.",

keywords = "Erythromycin a 6,9-hemiketal, Erythromycin a 8,9-dehydro-6,9-hemiketal, Erythromycin oxime",

author = "Dong Ye and Deng, {Zhi Hua} and Liang, {Jian Hua} and Jin, {Xiao Hong} and Bai, {Jing Rui} and Yao, {Guo Wei}",

year = "1999",

language = "English",

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journal = "He Jishu/Nuclear Techniques",

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T1 - Separation and identification of the main impurity in erythromycin oxime

AU - Ye, Dong

AU - Deng, Zhi Hua

AU - Liang, Jian Hua

AU - Jin, Xiao Hong

AU - Bai, Jing Rui

AU - Yao, Guo Wei

PY - 1999

Y1 - 1999

N2 - The oximation of erythromycin is studied. The main impurity involved in the synthesis of erythromycin oxime was separated and purified, which was identified as the very compound formed in the acidic hydrolysis of erythromycin A, i. e erythromycin A8,9-dehydro-6,9-hemiketal. This result shows that the oximation of erythromycin is always accompanied with its acidic degradation, and therefore that it is important to control the amount of acid used as catalyst.

AB - The oximation of erythromycin is studied. The main impurity involved in the synthesis of erythromycin oxime was separated and purified, which was identified as the very compound formed in the acidic hydrolysis of erythromycin A, i. e erythromycin A8,9-dehydro-6,9-hemiketal. This result shows that the oximation of erythromycin is always accompanied with its acidic degradation, and therefore that it is important to control the amount of acid used as catalyst.

KW - Erythromycin a 6,9-hemiketal

KW - Erythromycin a 8,9-dehydro-6,9-hemiketal

KW - Erythromycin oxime

UR - http://www.scopus.com/inward/record.url?scp=77449101807&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:77449101807

SN - 0253-3219

VL - 22

SP - 244-246+250

JO - He Jishu/Nuclear Techniques

JF - He Jishu/Nuclear Techniques

IS - 2

ER -

Separation and identification of the main impurity in erythromycin oxime

Abstract

Keywords

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