Preparation of highly purified nafronyl oxalate and Its X-ray single crystal structure

Min Xue; Jin Liang Wang; Wei Fa Yu; Dao Lin Wang; Jun Zhang; Zhi Ming Zhou

Preparation of highly purified nafronyl oxalate and Its X-ray single crystal structure

Min Xue^*, Jin Liang Wang, Wei Fa Yu, Dao Lin Wang, Jun Zhang, Zhi Ming Zhou

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Several different technological processes, including that of high vacuum fractionation, column chromatography and recrystallization, have been tried to reduce the quantity of impurities contained in the raw nafronyl oxalate. HPLC analysis showed that a combination of high vacuum distillation and water recrystallization led to a high quality product (99. 6% purity), meeting the British Pharmocoepia (1998) standard. X-ray single crystal analysis confirmed the structure of the title compound as first reported.

Original language	English
Pages (from-to)	658-661
Number of pages	4
Journal	He Jishu/Nuclear Techniques
Volume	22
Issue number	5
Publication status	Published - 1999

Keywords

Column chromatography
HPLC
High vacuum distillation
Impurity
Nafronyl oxalate
Single crystal structure

Cite this

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title = "Preparation of highly purified nafronyl oxalate and Its X-ray single crystal structure",

abstract = "Several different technological processes, including that of high vacuum fractionation, column chromatography and recrystallization, have been tried to reduce the quantity of impurities contained in the raw nafronyl oxalate. HPLC analysis showed that a combination of high vacuum distillation and water recrystallization led to a high quality product (99. 6% purity), meeting the British Pharmocoepia (1998) standard. X-ray single crystal analysis confirmed the structure of the title compound as first reported.",

keywords = "Column chromatography, HPLC, High vacuum distillation, Impurity, Nafronyl oxalate, Single crystal structure",

author = "Min Xue and Wang, {Jin Liang} and Yu, {Wei Fa} and Wang, {Dao Lin} and Jun Zhang and Zhou, {Zhi Ming}",

year = "1999",

language = "English",

volume = "22",

pages = "658--661",

journal = "He Jishu/Nuclear Techniques",

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T1 - Preparation of highly purified nafronyl oxalate and Its X-ray single crystal structure

AU - Xue, Min

AU - Wang, Jin Liang

AU - Yu, Wei Fa

AU - Wang, Dao Lin

AU - Zhang, Jun

AU - Zhou, Zhi Ming

PY - 1999

Y1 - 1999

N2 - Several different technological processes, including that of high vacuum fractionation, column chromatography and recrystallization, have been tried to reduce the quantity of impurities contained in the raw nafronyl oxalate. HPLC analysis showed that a combination of high vacuum distillation and water recrystallization led to a high quality product (99. 6% purity), meeting the British Pharmocoepia (1998) standard. X-ray single crystal analysis confirmed the structure of the title compound as first reported.

AB - Several different technological processes, including that of high vacuum fractionation, column chromatography and recrystallization, have been tried to reduce the quantity of impurities contained in the raw nafronyl oxalate. HPLC analysis showed that a combination of high vacuum distillation and water recrystallization led to a high quality product (99. 6% purity), meeting the British Pharmocoepia (1998) standard. X-ray single crystal analysis confirmed the structure of the title compound as first reported.

KW - Column chromatography

KW - HPLC

KW - High vacuum distillation

KW - Impurity

KW - Nafronyl oxalate

KW - Single crystal structure

UR - http://www.scopus.com/inward/record.url?scp=73549123625&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:73549123625

SN - 0253-3219

VL - 22

SP - 658

EP - 661

JO - He Jishu/Nuclear Techniques

JF - He Jishu/Nuclear Techniques

IS - 5

ER -

Preparation of highly purified nafronyl oxalate and Its X-ray single crystal structure

Abstract

Keywords

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