Preparation of azithromycin related substances

Cong Liu; Yan Jie Fu; Yi Jiao Nie; Guo Wei Yao; Li Quan Sun; Rong Ji Dai

Preparation of azithromycin related substances

Cong Liu, Yan Jie Fu, Yi Jiao Nie, Guo Wei Yao, Li Quan Sun, Rong Ji Dai^*

^*Corresponding author for this work

School of Life Science

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Six compounds were made by chemical synthesis or semi-preparative HPLC separation for azithromycin to promote quality and impurity control. They are erythromycin A 6, 9-imino ether, erythromycin A 9, 11-imino ether, 3'-N-demethyl azithromycin, 3'-N-[[4-(acetylamino)phenyl]sulphonyl]-3'-N-demethyl azithromycin, 3-decladinosylazithromycin and 12-dedeoxyazithromycin (azithromycin B), which were obtained through chemical synthesis or semi-preparative HPLC separation. Their structures are identified by MS, ¹H NMR and ¹³C NMR. The source and control methods of these impurities are also presented to improve azithromycin production process.

Original language	English
Pages (from-to)	106-110
Number of pages	5
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	34
Issue number	1
Publication status	Published - Jan 2014

Keywords

3'-N-demethylazithromycin
3-decladinosyl azithromycin
Azithromycin
Azithromycin B
Quality control
Related substance

Cite this

@article{dcdda8a32fde4454a81cb11526882c93,

title = "Preparation of azithromycin related substances",

abstract = "Six compounds were made by chemical synthesis or semi-preparative HPLC separation for azithromycin to promote quality and impurity control. They are erythromycin A 6, 9-imino ether, erythromycin A 9, 11-imino ether, 3'-N-demethyl azithromycin, 3'-N-[[4-(acetylamino)phenyl]sulphonyl]-3'-N-demethyl azithromycin, 3-decladinosylazithromycin and 12-dedeoxyazithromycin (azithromycin B), which were obtained through chemical synthesis or semi-preparative HPLC separation. Their structures are identified by MS, 1H NMR and 13C NMR. The source and control methods of these impurities are also presented to improve azithromycin production process.",

keywords = "3'-N-demethylazithromycin, 3-decladinosyl azithromycin, Azithromycin, Azithromycin B, Quality control, Related substance",

author = "Cong Liu and Fu, {Yan Jie} and Nie, {Yi Jiao} and Yao, {Guo Wei} and Sun, {Li Quan} and Dai, {Rong Ji}",

year = "2014",

month = jan,

language = "English",

volume = "34",

pages = "106--110",

journal = "Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology",

issn = "1001-0645",

publisher = "Beijing Institute of Technology",

number = "1",

}

TY - JOUR

T1 - Preparation of azithromycin related substances

AU - Liu, Cong

AU - Fu, Yan Jie

AU - Nie, Yi Jiao

AU - Yao, Guo Wei

AU - Sun, Li Quan

AU - Dai, Rong Ji

PY - 2014/1

Y1 - 2014/1

N2 - Six compounds were made by chemical synthesis or semi-preparative HPLC separation for azithromycin to promote quality and impurity control. They are erythromycin A 6, 9-imino ether, erythromycin A 9, 11-imino ether, 3'-N-demethyl azithromycin, 3'-N-[[4-(acetylamino)phenyl]sulphonyl]-3'-N-demethyl azithromycin, 3-decladinosylazithromycin and 12-dedeoxyazithromycin (azithromycin B), which were obtained through chemical synthesis or semi-preparative HPLC separation. Their structures are identified by MS, 1H NMR and 13C NMR. The source and control methods of these impurities are also presented to improve azithromycin production process.

AB - Six compounds were made by chemical synthesis or semi-preparative HPLC separation for azithromycin to promote quality and impurity control. They are erythromycin A 6, 9-imino ether, erythromycin A 9, 11-imino ether, 3'-N-demethyl azithromycin, 3'-N-[[4-(acetylamino)phenyl]sulphonyl]-3'-N-demethyl azithromycin, 3-decladinosylazithromycin and 12-dedeoxyazithromycin (azithromycin B), which were obtained through chemical synthesis or semi-preparative HPLC separation. Their structures are identified by MS, 1H NMR and 13C NMR. The source and control methods of these impurities are also presented to improve azithromycin production process.

KW - 3'-N-demethylazithromycin

KW - 3-decladinosyl azithromycin

KW - Azithromycin

KW - Azithromycin B

KW - Quality control

KW - Related substance

UR - http://www.scopus.com/inward/record.url?scp=84896926925&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84896926925

SN - 1001-0645

VL - 34

SP - 106

EP - 110

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 1

ER -

Preparation of azithromycin related substances

Abstract

Keywords

Other files and links

Fingerprint

Cite this