Abstract
One-pot synthesis is applied for the first time to prepare 9-deoxo-9a-aza-9a-homoerythromycin A (AZA). Sodium borohydride is added in situ while erythromycin 6, 9-imino ether is formed by Beckmann rearrangement from erythromycin A oxime in methanol. The results show the purity and yield of products are 90.5 % and 98.0 %, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 238-240 |
| Number of pages | 3 |
| Journal | Xiandai Huagong/Modern Chemical Industry |
| Volume | 26 |
| Issue number | SUPPL. |
| Publication status | Published - Jul 2006 |
Keywords
- 9-deoxo-9a-aza-9a-homoerythromycin A
- Azithromycin
- Erythromycin A oxime
- One spot synthesis