TY - JOUR
T1 - Pharmacokinetic interaction between cefaclor and bromhexine in healthy Chinese volunteers
AU - Gong, Qian
AU - Hu, Zhe Yi
AU - Huang, Zhi Zhuang
AU - Wang, Li Qing
AU - Liu, Wen Fang
AU - Guo, Xin
AU - Cao, Wei
AU - Wang, Ting
AU - Cheng, Ze Neng
PY - 2007/10
Y1 - 2007/10
N2 - Objective To determine the pharmacokinetic interaction between cefalor and bromhexine in healthy Chinese volunteers. Methods Twelve subjects received a cefaclor (CEF) treatment, a bromhexine (BHX) treatment, and a co-treatment of CEF and BHX with a 3 × 3 Latin square design. The wash-out time between periods was 14 days. The plasma and urine drug concentrations of CEF and BHX were detected by HPLC-UV and LC/MS, respectively. Results AU the 12 volunteers completed the study. There were no significant differences in AUC0-t, and Cmax of CEF in logarithm between the single administration group of CEF and the co - administration group of CEF with BHX. Two one sided t-test showed that CEF was bioequivalent in the 2 groups. There were no significant differences in tmax, MRT, t1/2, and Clr between the 2 groups. Vd/F was significantly lower in the single CEF group than in the co - administration group of CEF and BHX. There were no significant differences of AUC0-t and Cmax of BHX in logarithm between the single administration group of BHX and the co - administration group of BHX with CEF. Two one sided t-test showed that BHX was bioequivalent in the 2 groups. There were no significant differences in tmax, MRT, t 1/2, Vd/F, and Clr between the 2 groups. Conclusion There is no significant pharmacokinetic parameter change in the drug absorption, metabolism, and excretion, but Vd/F of CEF significant increases in the co-administration of CEF with BHX. The co-administration of CEF and BHX has no adverse drug interaction. The increase of Vd/F may be a favorable drug interaction, which may be the mechanism of the synergistic effect of the 2 drugs.
AB - Objective To determine the pharmacokinetic interaction between cefalor and bromhexine in healthy Chinese volunteers. Methods Twelve subjects received a cefaclor (CEF) treatment, a bromhexine (BHX) treatment, and a co-treatment of CEF and BHX with a 3 × 3 Latin square design. The wash-out time between periods was 14 days. The plasma and urine drug concentrations of CEF and BHX were detected by HPLC-UV and LC/MS, respectively. Results AU the 12 volunteers completed the study. There were no significant differences in AUC0-t, and Cmax of CEF in logarithm between the single administration group of CEF and the co - administration group of CEF with BHX. Two one sided t-test showed that CEF was bioequivalent in the 2 groups. There were no significant differences in tmax, MRT, t1/2, and Clr between the 2 groups. Vd/F was significantly lower in the single CEF group than in the co - administration group of CEF and BHX. There were no significant differences of AUC0-t and Cmax of BHX in logarithm between the single administration group of BHX and the co - administration group of BHX with CEF. Two one sided t-test showed that BHX was bioequivalent in the 2 groups. There were no significant differences in tmax, MRT, t 1/2, Vd/F, and Clr between the 2 groups. Conclusion There is no significant pharmacokinetic parameter change in the drug absorption, metabolism, and excretion, but Vd/F of CEF significant increases in the co-administration of CEF with BHX. The co-administration of CEF and BHX has no adverse drug interaction. The increase of Vd/F may be a favorable drug interaction, which may be the mechanism of the synergistic effect of the 2 drugs.
KW - Bromhexine
KW - Cefaclor
KW - Drug - Drug interaction
KW - HPLC
KW - LC - MS
UR - http://www.scopus.com/inward/record.url?scp=36749013696&partnerID=8YFLogxK
M3 - Article
C2 - 18007084
AN - SCOPUS:36749013696
SN - 1672-7347
VL - 32
SP - 855
EP - 861
JO - Journal of Central South University (Medical Sciences)
JF - Journal of Central South University (Medical Sciences)
IS - 5
ER -