Near-infrared photocontrolled therapeutic release via upconversion nanocomposites

Zhimin Wang; Do Cong Thang; Qingyu Han; Xuan Zhao; Xilei Xie; Zhiyong Wang; Jun Lin; Bengang Xing

doi:10.1016/j.jconrel.2020.05.011

Near-infrared photocontrolled therapeutic release via upconversion nanocomposites

Zhimin Wang, Do Cong Thang, Qingyu Han, Xuan Zhao, Xilei Xie, Zhiyong Wang, Jun Lin, Bengang Xing^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Photocontrolled therapeutic release holds great promise due to its versatile manipulability, superb spatiotemporal precision and minimal tissue invasiveness in biomedical purposes. However, most of light-responsive platforms thus far have relied on UV or visible light which substantially limit the potential applicability in living animals. In recent decades, near-infrared (NIR) light-mediated theranostic upconversion nanocomposites (UCNCs) that integrate conventional UV/Vis-sensitive materials and classic lanthanide-doped upconversion nanoparticles (UCNPs) have significantly promoted the development of deep-tissue photoreleasable therapeutics in vivo. Herein, we seek to review current NIR upconversion triggered photorelease techniques and their diverse applications in the biological regulation, as well as diseases therapy. In addition, the future perspectives and challenges for advancing UCNCs based NIR photoreleasable nanotherapeutics into clinical translations are proposed.

Original language	English
Pages (from-to)	104-123
Number of pages	20
Journal	Journal of Controlled Release
Volume	324
DOIs	https://doi.org/10.1016/j.jconrel.2020.05.011
Publication status	Published - 10 Aug 2020
Externally published	Yes

Keywords

Bioimaging
Near-infrared light
Photocontrolled release
Therapeutics
Upconversion nanocomposites

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10.1016/j.jconrel.2020.05.011

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title = "Near-infrared photocontrolled therapeutic release via upconversion nanocomposites",

abstract = "Photocontrolled therapeutic release holds great promise due to its versatile manipulability, superb spatiotemporal precision and minimal tissue invasiveness in biomedical purposes. However, most of light-responsive platforms thus far have relied on UV or visible light which substantially limit the potential applicability in living animals. In recent decades, near-infrared (NIR) light-mediated theranostic upconversion nanocomposites (UCNCs) that integrate conventional UV/Vis-sensitive materials and classic lanthanide-doped upconversion nanoparticles (UCNPs) have significantly promoted the development of deep-tissue photoreleasable therapeutics in vivo. Herein, we seek to review current NIR upconversion triggered photorelease techniques and their diverse applications in the biological regulation, as well as diseases therapy. In addition, the future perspectives and challenges for advancing UCNCs based NIR photoreleasable nanotherapeutics into clinical translations are proposed.",

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author = "Zhimin Wang and Thang, {Do Cong} and Qingyu Han and Xuan Zhao and Xilei Xie and Zhiyong Wang and Jun Lin and Bengang Xing",

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doi = "10.1016/j.jconrel.2020.05.011",

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AU - Wang, Zhimin

AU - Thang, Do Cong

AU - Han, Qingyu

AU - Zhao, Xuan

AU - Xie, Xilei

AU - Wang, Zhiyong

AU - Lin, Jun

AU - Xing, Bengang

PY - 2020/8/10

Y1 - 2020/8/10

N2 - Photocontrolled therapeutic release holds great promise due to its versatile manipulability, superb spatiotemporal precision and minimal tissue invasiveness in biomedical purposes. However, most of light-responsive platforms thus far have relied on UV or visible light which substantially limit the potential applicability in living animals. In recent decades, near-infrared (NIR) light-mediated theranostic upconversion nanocomposites (UCNCs) that integrate conventional UV/Vis-sensitive materials and classic lanthanide-doped upconversion nanoparticles (UCNPs) have significantly promoted the development of deep-tissue photoreleasable therapeutics in vivo. Herein, we seek to review current NIR upconversion triggered photorelease techniques and their diverse applications in the biological regulation, as well as diseases therapy. In addition, the future perspectives and challenges for advancing UCNCs based NIR photoreleasable nanotherapeutics into clinical translations are proposed.

AB - Photocontrolled therapeutic release holds great promise due to its versatile manipulability, superb spatiotemporal precision and minimal tissue invasiveness in biomedical purposes. However, most of light-responsive platforms thus far have relied on UV or visible light which substantially limit the potential applicability in living animals. In recent decades, near-infrared (NIR) light-mediated theranostic upconversion nanocomposites (UCNCs) that integrate conventional UV/Vis-sensitive materials and classic lanthanide-doped upconversion nanoparticles (UCNPs) have significantly promoted the development of deep-tissue photoreleasable therapeutics in vivo. Herein, we seek to review current NIR upconversion triggered photorelease techniques and their diverse applications in the biological regulation, as well as diseases therapy. In addition, the future perspectives and challenges for advancing UCNCs based NIR photoreleasable nanotherapeutics into clinical translations are proposed.

KW - Bioimaging

KW - Near-infrared light

KW - Photocontrolled release

KW - Therapeutics

KW - Upconversion nanocomposites

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VL - 324

SP - 104

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JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Near-infrared photocontrolled therapeutic release via upconversion nanocomposites

Abstract

Keywords

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