TY - JOUR
T1 - Nanoscale covalent organic frameworks
T2 - From controlled synthesis to cancer therapy
AU - He, Xuelu
AU - Jiang, Zhenqi
AU - Akakuru, Ozioma Udochukwu
AU - Li, Juan
AU - Wu, Aiguo
N1 - Publisher Copyright:
© The Royal Society of Chemistry.
PY - 2021/12/4
Y1 - 2021/12/4
N2 - Covalent organic frameworks (COFs), as a new type of crystalline porous materials, mainly consist of light-weight elements (H, B, C, N and O) linked by dynamic covalent bonds to form periodical structures of two or three dimensions. As an attribute of their low density, large surface area, and excellent adjustable pore size, COFs show great potential in many fields including energy storage and separation, catalysis, sensing, and biomedicine. However, compared with metal organic frameworks (MOFs), the relatively large size and irregular morphology of COFs affect their biocompatibility and bioavailability in vivo, thus impeding their further biomedical applications. This Review focuses on the controlled design strategies of nanoscale COFs (NCOFs), unique properties of NCOFs for biomedical applications, and recent progress in NCOFs for cancer therapy. In addition, current challenges for the biomedical use of NCOFs and perspectives for further improvements are presented.
AB - Covalent organic frameworks (COFs), as a new type of crystalline porous materials, mainly consist of light-weight elements (H, B, C, N and O) linked by dynamic covalent bonds to form periodical structures of two or three dimensions. As an attribute of their low density, large surface area, and excellent adjustable pore size, COFs show great potential in many fields including energy storage and separation, catalysis, sensing, and biomedicine. However, compared with metal organic frameworks (MOFs), the relatively large size and irregular morphology of COFs affect their biocompatibility and bioavailability in vivo, thus impeding their further biomedical applications. This Review focuses on the controlled design strategies of nanoscale COFs (NCOFs), unique properties of NCOFs for biomedical applications, and recent progress in NCOFs for cancer therapy. In addition, current challenges for the biomedical use of NCOFs and perspectives for further improvements are presented.
UR - http://www.scopus.com/inward/record.url?scp=85120335699&partnerID=8YFLogxK
U2 - 10.1039/d1cc04846e
DO - 10.1039/d1cc04846e
M3 - Article
C2 - 34734601
AN - SCOPUS:85120335699
SN - 1359-7345
VL - 57
SP - 12417
EP - 12435
JO - Chemical Communications
JF - Chemical Communications
IS - 93
ER -
