Multidrug resistance protein expression of adult T-cell leukemia/lymphoma

Takeshi Yasunami; Yan hua Wang; Kazue Tsuji; Minoko Takanashi; Yasuaki Yamada; Toshiko Motoji

doi:10.1016/j.leukres.2006.10.012

Multidrug resistance protein expression of adult T-cell leukemia/lymphoma

Takeshi Yasunami, Yan hua Wang, Kazue Tsuji, Minoko Takanashi, Yasuaki Yamada, Toshiko Motoji^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MDR proteins which we examined in ATL cells using multiparametric flow cytometry and real-time RT-PCR. LRP was highly expressed and suppressing LRP function increased doxorubicin accumulation in nuclei. This indicates LRP may be contributing to drug resistance in ATL patients, and the suppression of LRP function could be a new strategy for ATL treatment.

Original language	English
Pages (from-to)	465-470
Number of pages	6
Journal	Leukemia Research
Volume	31
Issue number	4
DOIs	https://doi.org/10.1016/j.leukres.2006.10.012
Publication status	Published - Apr 2007
Externally published	Yes

Keywords

Adult T-cell leukemia/lymphoma
Lung resistance-related protein (LRP)
Multidrug resistance protein (MDR)
Multidrug resistance-associated protein (MRP)
P-glycoprotein (P-gp)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2006.10.012

Cite this

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title = "Multidrug resistance protein expression of adult T-cell leukemia/lymphoma",

abstract = "In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MDR proteins which we examined in ATL cells using multiparametric flow cytometry and real-time RT-PCR. LRP was highly expressed and suppressing LRP function increased doxorubicin accumulation in nuclei. This indicates LRP may be contributing to drug resistance in ATL patients, and the suppression of LRP function could be a new strategy for ATL treatment.",

keywords = "Adult T-cell leukemia/lymphoma, Lung resistance-related protein (LRP), Multidrug resistance protein (MDR), Multidrug resistance-associated protein (MRP), P-glycoprotein (P-gp)",

author = "Takeshi Yasunami and Wang, {Yan hua} and Kazue Tsuji and Minoko Takanashi and Yasuaki Yamada and Toshiko Motoji",

year = "2007",

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doi = "10.1016/j.leukres.2006.10.012",

language = "English",

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pages = "465--470",

journal = "Leukemia Research",

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TY - JOUR

T1 - Multidrug resistance protein expression of adult T-cell leukemia/lymphoma

AU - Yasunami, Takeshi

AU - Wang, Yan hua

AU - Tsuji, Kazue

AU - Takanashi, Minoko

AU - Yamada, Yasuaki

AU - Motoji, Toshiko

PY - 2007/4

Y1 - 2007/4

N2 - In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MDR proteins which we examined in ATL cells using multiparametric flow cytometry and real-time RT-PCR. LRP was highly expressed and suppressing LRP function increased doxorubicin accumulation in nuclei. This indicates LRP may be contributing to drug resistance in ATL patients, and the suppression of LRP function could be a new strategy for ATL treatment.

AB - In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MDR proteins which we examined in ATL cells using multiparametric flow cytometry and real-time RT-PCR. LRP was highly expressed and suppressing LRP function increased doxorubicin accumulation in nuclei. This indicates LRP may be contributing to drug resistance in ATL patients, and the suppression of LRP function could be a new strategy for ATL treatment.

KW - Adult T-cell leukemia/lymphoma

KW - Lung resistance-related protein (LRP)

KW - Multidrug resistance protein (MDR)

KW - Multidrug resistance-associated protein (MRP)

KW - P-glycoprotein (P-gp)

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U2 - 10.1016/j.leukres.2006.10.012

DO - 10.1016/j.leukres.2006.10.012

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AN - SCOPUS:33846705561

SN - 0145-2126

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EP - 470

JO - Leukemia Research

JF - Leukemia Research

IS - 4

ER -

Multidrug resistance protein expression of adult T-cell leukemia/lymphoma

Abstract

Keywords

UN SDGs

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